Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides (Q34626861)

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scientific article published on 18 March 2013

Language	Label	Description	Also known as
English	Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides	scientific article published on 18 March 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

4 references

19 September 2019

13 November 2019

20 November 2019

16 October 2020

Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides (English)

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

biomedical investigative technique

1 reference

19 September 2019

polycyclic compound

1 reference

13 November 2019

1 reference

20 November 2019

1 reference

16 October 2020

natural product

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

author name string

Kenichiro Ito

1

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

Hiroaki Suga

3

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

language of work or name

0 references

publication date

18 March 2013

5 references

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

19 September 2019

13 November 2019

20 November 2019

16 October 2020

5 references

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

19 September 2019

13 November 2019

20 November 2019

16 October 2020

18

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

3

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

3502-3528

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

copyright license

Creative Commons Attribution 3.0 Unported

4 references

Europe PubMed Central

19 September 2019

Europe PubMed Central

13 November 2019

Europe PubMed Central

20 November 2019

Europe PubMed Central

16 October 2020

copyright status

0 references

The impact of natural products upon modern drug discovery.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

The exploration of macrocycles for drug discovery--an underexploited structural class

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

How nature morphs peptide scaffolds into antibiotics

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Bioengineering natural product biosynthetic pathways for therapeutic applications.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

In vitro virus: Bonding of mRNA bearing puromycin at the 3′‐terminal end to the C‐terminal end of its encoded protein on the ribosome in vitro

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

RNA-peptide fusions for the in vitro selection of peptides and proteins

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Cell-free translation reconstituted with purified components

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

The RNA origin of transfer RNA aminoacylation and beyond.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

The flexizyme system: a highly flexible tRNA aminoacylation tool for the translation apparatus

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Programmable ribozymes for mischarging tRNA with nonnatural amino acids and their applications to translation

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of backbone macrocyclic peptides.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of nonstandard peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Synthesis of biopolymers using genetic code reprogramming

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Beyond the canonical 20 amino acids: expanding the genetic lexicon

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Reprogramming the genetic code: from triplet to quadruplet codes.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

A highly flexible tRNA acylation method for non-natural polypeptide synthesis

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Initiating translation with D-amino acids

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Translation initiation with initiator tRNA charged with exotic peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Synthesis of polyester by means of genetic code reprogramming

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

A versatile tRNA aminoacylation catalyst based on RNA.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Diverse backbone-cyclized peptides via codon reprogramming

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Programming peptidomimetic syntheses by translating genetic codes designed de novo

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosome-catalyzed polyester formation

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of backbone-macrocyclic peptides containing γ-amino acids.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

DNA display for in vitro selection of diverse peptide libraries

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

In vitro selection and evolution of functional proteins by using ribosome display

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Psoralen photo-crosslinked mRNA-puromycin conjugates: a novel template for the rapid and facile preparation of mRNA-protein fusions

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

An efficient ligation method in the making of an in vitro virus for in vitro protein evolution

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Optimized synthesis of RNA-protein fusions for in vitro protein selection

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

mRNA display-based selections using synthetic peptide and natural protein libraries

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Hit and lead generation: beyond high-throughput screening

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Activation of AKT kinases in cancer: implications for therapeutic targeting

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

The human Sir2 ortholog, SIRT2, is an NAD -dependent tubulin deacetylase

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

E6AP promotes the degradation of the PML tumor suppressor

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Targeting the ubiquitin system in cancer therapy

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Enzymatic aminoacylation of tRNA with unnatural amino acids

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of N-methyl peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

In vitro selection of functional lantipeptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Discovery, biosynthesis, and engineering of lantipeptides

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X.

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Artificial lantipeptides from in vitro translations

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

A general route for post-translational cyclization of mRNA display libraries

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Design of cyclic peptides that bind protein surfaces with antibody-like affinity

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Genetic diseases associated with heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Fresh from the biologic pipeline—2010

1 reference

https://api.crossref.org/works/10.3390/MOLECULES18033502

21 January 2018

Encodamers: unnatural peptide oligomers encoded in RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A flexizyme that selectively charges amino acids activated by a water-friendly leaving group

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of the Backbone Cyclic Peptide Sunflower Trypsin Inhibitor‐1 Promoted by the Induced Peptidyl‐tRNA Drop‐off

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flexizymes for genetic code reprogramming

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flexizymes: their evolutionary history and the origin of catalytic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/23507778

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MOLECULES18033502

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6270345

ResearchGate publication ID

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