The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use. (Q34626755)

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English	The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use. (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

endocannabinoid system

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cannabinoid receptor

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author name string

S Xie

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

M A Furjanic

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

J J Ferrara

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

N R McAndrew

4

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Europe PubMed Central

PubMed publication ID

3 August 2017

E L Ardino

5

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Europe PubMed Central

PubMed publication ID

3 August 2017

A Ngondara

6

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Europe PubMed Central

PubMed publication ID

3 August 2017

Y Bernstein

7

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Europe PubMed Central

PubMed publication ID

3 August 2017

K J Thomas

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

E Kim

9

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Europe PubMed Central

PubMed publication ID

3 August 2017

J M Walker

10

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Europe PubMed Central

PubMed publication ID

3 August 2017

S Nagar

11

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Europe PubMed Central

PubMed publication ID

3 August 2017

S J Ward

12

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Europe PubMed Central

PubMed publication ID

3 August 2017

R B Raffa

13

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Europe PubMed Central

PubMed publication ID

3 August 2017

publication date

1 June 2007

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Europe PubMed Central

PubMed publication ID

3 August 2017

Journal of Clinical Pharmacy and Therapeutics

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Europe PubMed Central

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3 August 2017

32

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Europe PubMed Central

PubMed publication ID

3 August 2017

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

209-231

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Europe PubMed Central

PubMed publication ID

3 August 2017

The emerging role of the endocannabinoid system in endocrine regulation and energy balance

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

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21 January 2018

Oleamide: a member of the endocannabinoid family?

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21 January 2018

The endocannabinoid system as an emerging target of pharmacotherapy

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor

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21 January 2018

Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

P2X7 receptors control 2-arachidonoylglycerol production by microglial cells

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids

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21 January 2018

Endocannabinoid signaling in the brain

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Role of endogenous cannabinoids in synaptic signaling

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid receptor localization in brain

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Varying Body Mass Index Cutoff Points to Describe Overweight Prevalence Among U. S. Adults: NHANES III (1988 to 1994)

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Obesity and the regulation of energy balance

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Surgical approaches to obesity

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Obesity: new perspectives and pharmacotherapies

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The religious and medicinal uses of Cannabis in China, India and Tibet

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Tetrahydrocannabinol and endocannabinoids in feeding and appetite

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The actions of the cannabinoid receptor antagonist, SR 141716A, in the rat isolated mesenteric artery.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Rimonabant: the first therapeutically relevant cannabinoid antagonist

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https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The anti-obesity effect of rimonabant is associated with an improved serum lipid profile

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-58630).

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

The functional neuroanatomy of brain cannabinoid receptors

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Accumbens dopamine mechanisms in sucrose intake

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Leptin-regulated endocannabinoids are involved in maintaining food intake

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

A role for lateral hypothalamic orexin neurons in reward seeking

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

From lesions to leptin: hypothalamic control of food intake and body weight.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid transmission and reward-related events

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Synergistic efects of opioid and cannabinoid antagonists on food intake

1 reference

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21 January 2018

The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of the cannabinoid CB(1) receptor antagonist, SR141716A, after Delta(9)-tetrahydrocannabinol withdrawal

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoids and neuroinflammation

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Involvement of the endocannabinoid system in drug addiction

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

A cannabinoid mechanism in relapse to cocaine seeking.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid CB1 receptors control conditioned drug seeking

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716).

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Advances in schizophrenia

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cortical inhibitory neurons and schizophrenia

1 reference

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21 January 2018

The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of AM281, a cannabinoid antagonist, on circulatory deterioration and cytokine production in an endotoxin shock model: comparison with norepinephrine.

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents

1 reference

https://api.crossref.org/works/10.1111/J.1365-2710.2007.00817.X

21 January 2018

Identifiers

10.1111/J.1365-2710.2007.00817.X

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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