Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer. (Q34625171)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25447675 AND SRC:MED&resulttype=core&format=json

23 February 2020

review article

1 reference

title

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer (English)

1 reference

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23 February 2020

2

1 reference

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23 February 2020

author name string

Mariya O Krisenko

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25447675 AND SRC:MED&resulttype=core&format=json

23 February 2020

language of work or name

English

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publication date

4 November 2014

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Biochimica et Biophysica Acta

23 February 2020

published in

1 reference

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23 February 2020

volume

1853

1 reference

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23 February 2020

issue

1

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23 February 2020

page(s)

254-263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25447675 AND SRC:MED&resulttype=core&format=json

Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

23 February 2020

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Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.

7 July 2018

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Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer

7 July 2018

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SYK is a critical regulator of FLT3 in acute myeloid leukemia

7 July 2018

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SYK allelic loss and the role of Syk-regulated genes in breast cancer survival.

7 July 2018

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Expression of variant isoforms of the tyrosine kinase SYK determines the prognosis of hepatocellular carcinoma.

7 July 2018

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The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.

7 July 2018

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T-cell receptor signaling in peripheral T-cell lymphoma - a review of patterns of alterations in a central growth regulatory pathway

7 July 2018

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New insights into pre-BCR and BCR signalling with relevance to B cell malignancies

7 July 2018

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In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

7 July 2018

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SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas

7 July 2018

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Hypermethylation and prognostic implication of Syk gene in human colorectal cancer

7 July 2018

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Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

7 July 2018

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Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

7 July 2018

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SYK regulates mTOR signaling in AML.

7 July 2018

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β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis

7 July 2018

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The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

7 July 2018

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Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia.

7 July 2018

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Structural and biophysical characterization of the Syk activation switch

7 July 2018

1 reference

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Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

7 July 2018

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5-aza-CdR induces the demethylation of Syk promoter in nasopharyngeal carcinoma cell

7 July 2018

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Epstein-Barr Virus Latent Membrane Protein-2A Induces ITAM/Syk- and Akt-Dependent Epithelial Migration through αV-Integrin Membrane Translocation

7 July 2018

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CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.

7 July 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

7 July 2018

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Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

7 July 2018

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A novel retinoblastoma therapy from genomic and epigenetic analyses

7 July 2018

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SYK inhibition and response prediction in diffuse large B-cell lymphoma

7 July 2018

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Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus (EBV ) B cell lymphomas

7 July 2018

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7 July 2018

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7 July 2018

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Alternative splicing of SYK regulates mitosis and cell survival

7 July 2018

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7 July 2018

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Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor

7 July 2018

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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

7 July 2018

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A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

7 July 2018

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The SYK tyrosine kinase: a crucial player in diverse biological functions

7 July 2018

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The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

7 July 2018

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Epstein-Barr virus in Burkitt's lymphoma: a role for latent membrane protein 2A

7 July 2018

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STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

7 July 2018

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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

7 July 2018

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

7 July 2018

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BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

7 July 2018

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Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion

7 July 2018

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PI3 kinase signals BCR-dependent mature B cell survival

7 July 2018

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BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt.

7 July 2018

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Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo

7 July 2018

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Proteomic and genetic approaches identify Syk as an AML target

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Phosphoproteomic analysis of Syk kinase signaling in human cancer cells reveals its role in cell-cell adhesion.

7 July 2018

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Syk and pTyr'd: Signaling through the B cell antigen receptor

7 July 2018

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Tyrosine phosphorylation: thirty years and counting

7 July 2018

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Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

7 July 2018

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Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

7 July 2018

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Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas.

7 July 2018

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The BCL-2 protein family: opposing activities that mediate cell death

7 July 2018

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ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

7 July 2018

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SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

7 July 2018

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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

7 July 2018

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Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck

7 July 2018

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The expanding role for ITAM-based signaling pathways in immune cells

7 July 2018

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Epigenetic silencing of novel tumor suppressors in malignant melanoma

7 July 2018

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Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma

7 July 2018

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

7 July 2018

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mTOR, translation initiation and cancer

7 July 2018

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Syk-dependent mTOR activation in follicular lymphoma cells.

7 July 2018

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Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation

7 July 2018

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Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells

7 July 2018

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Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase

7 July 2018

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ITAM-mediated tonic signalling through pre-BCR and BCR complexes

7 July 2018

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The Syk tyrosine kinase: a new negative regulator in tumor growth and progression.

7 July 2018

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Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells

7 July 2018

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Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

7 July 2018

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The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression.

7 July 2018

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Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression

7 July 2018

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The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells.

7 July 2018

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Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis

7 July 2018

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The role of CD22 and other inhibitory co-receptors in B-cell activation

7 July 2018

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MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture

7 July 2018

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Intrinsic tumour suppression

7 July 2018

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Progressive loss of Syk and abnormal proliferation in breast cancer cells

7 July 2018

1 reference

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Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

7 July 2018

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Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

7 July 2018

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The STATs of cancer--new molecular targets come of age

7 July 2018

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TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways

7 July 2018

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Immunobiology of chronic lymphocytic leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Syk expression and novel function in a wide variety of tissues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Structure and function of Syk protein-tyrosine kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

A public database for gene expression in human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Physical and functional association of cortactin with Syk in human leukemic cell line K562

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Purification and characterization of a cytosolic protein-tyrosine kinase from porcine spleen

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Splenic marginal zone lymphoma: comprehensive analysis of gene expression and miRNA profiling.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Redundant role for Zap70 in B cell development and activation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Hypermethylation leads to silencing of the SYK gene in human breast cancer.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254495

Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer

26 October 2018

1 reference

12 December 2020

Purification and characterization of a protein-tyrosine kinase from bovine thymus

1 reference

12 December 2020

Tyrosine kinases as targets for cancer therapy

1 reference

12 December 2020

The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease

1 reference

12 December 2020

XIAP, the guardian angel

1 reference

12 December 2020

Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis

1 reference

12 December 2020

10.1016/J.BBAMCR.2014.10.022

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25447675 AND SRC:MED&resulttype=core&format=json

release_tfnksal36zeujepvrm76neszye

23 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tfnksal36zeujepvrm76neszye

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25447675 AND SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

25447675

1 reference