Does Huntingtin play a role in selective macroautophagy? (Q34618914)

3 August 2017

1 reference

title

Does Huntingtin play a role in selective macroautophagy? (English)

1 reference

3 August 2017

Joan S Steffan

1

1 reference

3 August 2017

publication date

1 September 2010

1 reference

3 August 2017

number of pages

13

1 reference

inferred from page(s)

published in

Cell Cycle

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3 August 2017

volume

9

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3 August 2017

issue

17

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3 August 2017

page(s)

3401-3413

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Genetic bases for glaucoma

3 August 2017

cites work

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7 July 2018

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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mTOR signaling at a glance

7 July 2018

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7 July 2018

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7 July 2018

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Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy

7 July 2018

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Peroxisome size provides insights into the function of autophagy-related proteins

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae

7 July 2018

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Structural basis of target recognition by Atg8/LC3 during selective autophagy

7 July 2018

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7 July 2018

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Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

7 July 2018

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Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins

7 July 2018

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Proteolytic and lipolytic responses to starvation

7 July 2018

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NF-kappaB activation by reactive oxygen species: fifteen years later

7 July 2018

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Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

7 July 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

7 July 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

7 July 2018

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

7 July 2018

1 reference

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Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

7 July 2018

1 reference

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Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease

7 July 2018

1 reference

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Roles for NF-kappaB in nerve cell survival, plasticity, and disease

7 July 2018

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Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.

7 July 2018

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

7 July 2018

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The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae

7 July 2018

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Lithium induces autophagy by inhibiting inositol monophosphatase

7 July 2018

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

7 July 2018

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

7 July 2018

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Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

The molecular machinery of autophagy: unanswered questions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

7 July 2018

Signaling to NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

The phox homology (PX) domain protein interaction network in yeast

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

SUMO modification of Huntingtin and Huntington's disease pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

The hunt for huntingtin function: interaction partners tell many different stories

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

The molecular mechanism of autophagy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Interaction of Huntington disease protein with transcriptional activator Sp1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Comparison of ARM and HEAT protein repeats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

The heat shock protein Ssa2p is required for import of fructose-1, 6-bisphosphatase into Vid vesicles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047613

Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

7 July 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

A cycling protein complex required for selective autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

CRE-mediated transcription is increased in Huntington's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

The selfish brain: competition for energy resources

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Palmitoylation determines the function of Vac8 at the yeast vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

Autophagy: links with the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161/CC.9.17.12718

LAMP-2: a control step for phagosome and autophagosome maturation

21 January 2018

1 reference

12 December 2020

Targeting of aminopeptidase I to the yeast vacuole is mediated by Ssa1p, a cytosolic member of the 70-kDa stress protein family

1 reference

12 December 2020

Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes

1 reference

12 December 2020

ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes

1 reference

12 December 2020

Toll-like receptors: roles in neuroprotection?

1 reference

12 December 2020

Identifiers

DOI

10.4161/CC.9.17.12718

1 reference

3 August 2017

1 reference

3 August 2017

1 reference