Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions. (Q34605137)

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22 January 2020

review article

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title

Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions (English)

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22 January 2020

1

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22 January 2020

2

Derya Unutmaz

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22 January 2020

author name string

Anthony A Gaspari

series ordinal

3

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22 January 2020

language of work or name

English

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publication date

5 March 2009

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Journal of Investigative Dermatology

22 January 2020

published in

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22 January 2020

volume

129

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22 January 2020

issue

7

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22 January 2020

page(s)

1628-1642

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Role of regulatory T cells in allergy and asthma

22 January 2020

cites work

1 reference

7 January 2021

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

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7 January 2021

Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells.

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7 January 2021

Th2 bias of CD4 NKT cells derived from multiple sclerosis in remission

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7 January 2021

Yes T cells, but three different T cells (alphabeta, gammadelta and NK T cells), and also B-1 cells mediate contact sensitivity

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7 January 2021

Extravascular T-cell recruitment requires initiation begun by Valpha14 NKT cells and B-1 B cells

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7 January 2021

Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule

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7 January 2021

NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells

1 reference

7 January 2021

In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers

1 reference

7 January 2021

Parallels and distinctions between T and NKT cell development in the thymus.

1 reference

7 January 2021

Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells

1 reference

7 January 2021

CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor

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7 January 2021

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.

1 reference

7 January 2021

CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

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7 January 2021

CD1d ligands: the good, the bad, and the ugly

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7 January 2021

Natural killer and natural killer-T cells in psoriasis

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7 January 2021

Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity

1 reference

7 January 2021

Invariant NKT cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity

1 reference

7 January 2021

Impaired NK1 T cell development and early IL-4 production in CD1-deficient mice.

1 reference

7 January 2021

The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models

1 reference

7 January 2021

Asthma: mechanisms of disease persistence and progression

1 reference

7 January 2021

Differential antitumor immunity mediated by NKT cell subsets in vivo

1 reference

7 January 2021

Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells

1 reference

7 January 2021

Evidence for the generation of suppressor cells by ultraviolet radiation

1 reference

7 January 2021

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells

1 reference

7 January 2021

Prevention of diabetes in nonobese diabetic mice mediated by CD1d-restricted nonclassical NKT cells

1 reference

7 January 2021

Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions

1 reference

7 January 2021

CD1d restricted natural killer T cells are not required for allergic skin inflammation

1 reference

7 January 2021

Liver NKT cells: an account of heterogeneity

1 reference

7 January 2021

CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes

1 reference

7 January 2021

Up-regulation of CD1d expression restores the immunoregulatory function of NKT cells and prevents autoimmune diabetes in nonobese diabetic mice

1 reference

7 January 2021

Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

1 reference

7 January 2021

Ceramide-dependent regulation of human epidermal keratinocyte CD1d expression during terminal differentiation

1 reference

7 January 2021

Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis

1 reference

7 January 2021

Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated Mice

1 reference

7 January 2021

Severe and selective deficiency of interferon-gamma-producing invariant natural killer T cells in patients with myelodysplastic syndromes

1 reference

7 January 2021

Modulation of murine experimental allergic conjunctivitis by treatment with alpha-galactosylceramide

1 reference

7 January 2021

Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma

1 reference

7 January 2021

Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis

1 reference

7 January 2021

Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis

1 reference

7 January 2021

NKT cells: facts, functions and fallacies.

1 reference

7 January 2021

Going both ways: immune regulation via CD1d-dependent NKT cells

1 reference

7 January 2021

NKT cells: what's in a name?

1 reference

7 January 2021

alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria

1 reference

7 January 2021

Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines

1 reference

7 January 2021

The trafficking of natural killer cells

1 reference

7 January 2021

CD1-specific T cells in microbial immunity

1 reference

7 January 2021

Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining

1 reference

7 January 2021

Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-gamma

1 reference

7 January 2021

alpha/beta-T cell receptor (TCR) CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10.

1 reference

7 January 2021

Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex

1 reference

7 January 2021

Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation.

1 reference

7 January 2021

Alpha-galactosylceramide: potential immunomodulatory activity and future application

1 reference

7 January 2021

Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide

1 reference

7 January 2021

Insights into the immunopathogenesis of multiple sclerosis

1 reference

7 January 2021

CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion

1 reference

7 January 2021

Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice.

1 reference

7 January 2021

Atopic dermatitis and Valpha24 natural killer T cells

1 reference

7 January 2021

Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy

1 reference

7 January 2021

Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells

1 reference

7 January 2021

Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide

1 reference

7 January 2021

NK T cells contribute to expansion of CD8( ) T cells and amplification of antiviral immune responses to respiratory syncytial virus

1 reference

7 January 2021

Natural killer T cells: a bridge to tolerance or a pathway to rejection?

1 reference

7 January 2021

Monocyte chemoattractant protein-1-dependent increase of V alpha 14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection.

1 reference

7 January 2021

CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides

1 reference

7 January 2021

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells

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7 January 2021

NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production

1 reference

7 January 2021

V alpha14 i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes

1 reference

7 January 2021

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria

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7 January 2021

Recognition of bacterial glycosphingolipids by natural killer T cells

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7 January 2021

The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells

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7 January 2021

Dysfunction of T cell receptor AV24AJ18 , BV11 double-negative regulatory natural killer T cells in autoimmune diseases

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7 January 2021

The unconventional lifestyle of NKT cells

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7 January 2021

Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis

1 reference

7 January 2021

Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi

1 reference

7 January 2021

NK T cell-induced protection against diabetes in V alpha 14-J alpha 281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen

1 reference

7 January 2021

Distinct functional lineages of human V(alpha)24 natural killer T cells

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7 January 2021

Testing the NKT cell hypothesis of human IDDM pathogenesis

1 reference

7 January 2021

Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes.

1 reference

7 January 2021

Increased expression of the natural killer cell inhibitory receptor CD94/NKG2A and CD158b on circulating and lesional T cells in patients with chronic plaque psoriasis

1 reference

7 January 2021

Immunoregulation of autoimmunity by natural killer T cells

1 reference

7 January 2021

Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis

1 reference

7 January 2021

Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model

1 reference

7 January 2021

Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells

1 reference

7 January 2021

The pathophysiology of asthma

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7 January 2021

Decreased TCR AV24AJ18 double-negative T cells in rheumatoid synovium

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7 January 2021

Relationships between natural T cells, atopy, IgE levels, and IL-4 production.

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7 January 2021

Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.

1 reference

7 January 2021

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

1 reference

7 January 2021

Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers

1 reference

7 January 2021

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

1 reference

7 January 2021

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

1 reference

7 January 2021

Immunology: hepatitis A virus link to atopic disease

1 reference

7 January 2021

Natural killer T cells: rapid responders controlling immunity and disease

1 reference

7 January 2021

Glycolipid activation of invariant T cell receptor NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4 T cells

1 reference

7 January 2021

Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases

1 reference

7 January 2021

Therapeutic potential of CD1d-restricted invariant natural killer T cell-based treatment for autoimmune diseases

1 reference

7 January 2021

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

1 reference

7 January 2021

Immune suppression and skin cancer development: regulation by NKT cells.

1 reference

7 January 2021

Tissue-specific expansion of NKT and CD5 B cells at the onset of autoimmune disease in (NZBxNZW)F1 mice

1 reference

7 January 2021

Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice

1 reference

7 January 2021

Natural killer T cells accelerate atherogenesis in mice

1 reference

7 January 2021

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

1 reference

7 January 2021

Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system

1 reference

7 January 2021

CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung

1 reference

7 January 2021

CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity

1 reference

7 January 2021

Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

1 reference

7 January 2021

Preferential T(h)2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo

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7 January 2021

Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity.

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7 January 2021

TCR Valpha14 natural killer T cells function as effector T cells in mice with collagen-induced arthritis

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7 January 2021

CD4-CD8- T cells bearing invariant Valpha24JalphaQ TCR alpha-chain are decreased in patients with atopic diseases

1 reference

7 January 2021

Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides

1 reference

7 January 2021

CD56brightCD16(-) NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation

1 reference

7 January 2021

Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cells

1 reference

7 January 2021

Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids

1 reference

7 January 2021

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain

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7 January 2021

Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency

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7 January 2021

Frequency of V?24CD161 natural killer T cells and invariant TCRAV24-AJ18 transcripts in atopic and non-atopic individuals

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7 January 2021

The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation

1 reference

7 January 2021

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

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7 January 2021

Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide

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7 January 2021

Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion

1 reference

7 January 2021

Valpha14 NKT cell-mediated anti-tumor responses and their clinical application

1 reference

7 January 2021

Natural killer T cell-mediated antitumor immune responses and their clinical applications

1 reference

7 January 2021

Functional roles of NKT cell in the immune system

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7 January 2021

Functionally distinct NKT cell subsets and subtypes

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7 January 2021

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

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7 January 2021

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex.

1 reference

7 January 2021

CD1-Restricted T cells: T cells with a unique immunological niche

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7 January 2021

Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.

1 reference

7 January 2021

Role of CD1d-restricted NKT cells in microbial immunity

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7 January 2021

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

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7 January 2021

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.

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7 January 2021

NKT cells - conductors of tumor immunity?

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7 January 2021

Sequential production of interferon-gamma by NK1.1 T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramide

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7 January 2021

NKT cells and tumor immunity—a double-edged sword

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7 January 2021

The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent

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7 January 2021

Differential tumor surveillance by natural killer (NK) and NKT cells.

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7 January 2021

Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells

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7 January 2021

Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals

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7 January 2021

Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells

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7 January 2021

Invariant NKT cells as initiators, licensors, and facilitators of the adaptive immune response

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7 January 2021

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

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7 January 2021

Loss of IFN-gamma production by invariant NK T cells in advanced cancer.

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7 January 2021

V alpha 24 natural killer T cells are markedly decreased in atopic dermatitis patients

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7 January 2021

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

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7 January 2021

A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance

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7 January 2021

The epidemiology of contact allergy in the general population--prevalence and main findings

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7 January 2021

The unique role of natural killer T cells in the response to microorganisms

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7 January 2021

CD1d-dependent activation of NKT cells aggravates atherosclerosis.

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7 January 2021

Asthma: an epidemic of dysregulated immunity

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7 January 2021

The immunoregulatory role of CD1d-restricted natural killer T cells in disease.

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7 January 2021

Circulating V(alpha24 ) Vbeta11 NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage

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7 January 2021

Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells

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7 January 2021

Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease.

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7 January 2021

Memory effector (CD45RO ) and cytotoxic (CD8 ) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late

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7 January 2021

CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes

1 reference

7 January 2021

The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion

1 reference

7 January 2021

Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity

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7 January 2021

Heterogeneity of CD4( ) and CD8( ) T cells

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7 January 2021

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells

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7 January 2021

Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide

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7 January 2021

The C-Glycoside Analogue of the Immunostimulantα-Galactosylceramide (KRN7000): Synthesis and Striking Enhancement of Activity

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7 January 2021

Repeated -Galactosylceramide Administration Results in Expansion of NK T Cells and Alleviates Inflammatory Dermatitis in MRL-lpr/lpr Mice

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7 January 2021

Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides

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7 January 2021

Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity

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7 January 2021

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

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7 January 2021

Activation of keratinocyte protein kinase C zeta in psoriasis plaques

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7 January 2021

Lysosomal glycosphingolipid recognition by NKT cells

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7 January 2021

Identifiers

DOI

10.1038/JID.2009.30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19262602 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

22 January 2020

1015447961

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