The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease (Q34600282)

3 August 2017

title

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease (English)

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polycystic kidney disease

3 August 2017

main subject

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inferred from title

author

Albrecht Kramer-Zucker

10

object named as

Albrecht Kramer-Zucker

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3 August 2017

author name string

Jonathan M Shillingford

1

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3 August 2017

Noel S Murcia

2

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3 August 2017

Claire H Larson

3

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3 August 2017

Seng Hui Low

4

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3 August 2017

Ryan Hedgepeth

5

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3 August 2017

Nicole Brown

6

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3 August 2017

Chris A Flask

7

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3 August 2017

Andrew C Novick

8

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3 August 2017

David A Goldfarb

9

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3 August 2017

Gerd Walz

11

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3 August 2017

Klaus B Piontek

12

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3 August 2017

Gregory G Germino

13

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3 August 2017

Thomas Weimbs

14

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3 August 2017

language of work or name

English

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publication date

27 March 2006

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

103

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3 August 2017

issue

14

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3 August 2017

page(s)

5466-5471

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Rheb binds and regulates the mTOR kinase

3 August 2017

cites work

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

7 July 2018

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7 July 2018

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7 July 2018

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

7 July 2018

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

7 July 2018

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Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

7 July 2018

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Regulation of translation initiation by FRAP/mTOR

7 July 2018

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Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

7 July 2018

1 reference

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Progressive segregation of unmyelinated axons in peripheral nerves, myelin alterations in the CNS, and cyst formation in the kidneys of myelin and lymphocyte protein-overexpressing mice

7 July 2018

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VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells

7 July 2018

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Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2

7 July 2018

1 reference

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

7 July 2018

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Renal Cystic Disease in Tuberous Sclerosis: Role of the Polycystic Kidney Disease 1 Gene

7 July 2018

1 reference

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

7 July 2018

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TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

7 July 2018

1 reference

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Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

7 July 2018

1 reference

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Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine

26 October 2018

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Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study

26 October 2018

1 reference

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Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice

26 October 2018

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12 December 2020

Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease

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12 December 2020

Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues

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12 December 2020

Cellular localization and tissue distribution of polycystin-1

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12 December 2020

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo

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12 December 2020

Autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Polycystic kidney disease

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0509694103

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3 August 2017

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3 August 2017

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