Epigenomics and epigenetic therapy of cancer (Q34583889)

3 August 2017

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title

Epigenomics and epigenetic therapy of cancer (English)

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3 August 2017

Gordon Strathdee

2

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author name string

Robert Brown

series ordinal

1

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3 August 2017

publication date

1 January 2002

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Trends in Molecular Medicine

3 August 2017

published in

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3 August 2017

volume

8

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3 August 2017

issue

4 Suppl

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3 August 2017

page(s)

S43-8

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Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

3 August 2017

cites work

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Methylation-induced repression--belts, braces, and chromatin

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The "dark side" of chromatin remodeling: repressive effects on transcription

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

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Demethylase activity is directed by histone acetylation

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DNA methyltransferase Dnmt1 associates with histone deacetylase activity

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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

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Suppression of intestinal neoplasia by DNA hypomethylation.

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X-chromosome inactivation in mammals

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Genomic imprinting in mammals.

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The human histone deacetylase family

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene

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Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation

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Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2'-deoxycytidine

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Identifiers

DOI

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3 August 2017

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