Progress in understanding the structure-activity relationships of P-glycoprotein (Q34581554)

3 August 2017

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title

Progress in understanding the structure-activity relationships of P-glycoprotein (English)

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3 August 2017

Terry R Stouch

1

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3 August 2017

Olafur Gudmundsson

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 March 2002

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Advanced Drug Delivery Reviews

3 August 2017

published in

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3 August 2017

volume

54

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3 August 2017

issue

3

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3 August 2017

page(s)

315-328

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

3 August 2017

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Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

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P-glycoprotein--a mediator of multidrug resistance in tumour cells

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

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P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid

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P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs

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Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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New triazine derivatives as potent modulators of multidrug resistance

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New purines and purine analogs as modulators of multidrug resistance

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Photoaffinity substrates for P-glycoprotein

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A novel method for direct and fluorescence independent determination of drug efflux out of leukemic blast cells

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Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

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Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells

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A biophysical model of passive and polarized active transport processes in Caco-2 cells: approaches to uncoupling apical and basolateral membrane events in the intact cell

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Drug-stimulated ATPase activity of the human P-glycoprotein

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Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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7 January 2021

The effects of lipids and detergents on ATPase-active P-glycoprotein

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7 January 2021

Progress in predicting human ADME parameters in silico

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7 January 2021

How does P-glycoprotein recognize its substrates?

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7 January 2021

Structure-activity relationships of multidrug resistance reversers

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7 January 2021

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

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7 January 2021

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

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A general pattern for substrate recognition by P‐glycoprotein

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Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein

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Structure-activity relationship of P-glycoprotein substrates and modifiers

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Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics.

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Prediction of drug transport processes using simple parameters and PLS statistics. The use of ACD/logP and ACD/ChemSketch descriptors.

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7 January 2021

Quantitative Structure-Activity Relationship of Multidrug Resistance Reversal Agents

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Reversal of multidrug resistance by phenothiazines and structurally related compounds

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7 January 2021

Pharmacokinetics and metabolism in early drug discovery

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7 January 2021

Communication between multiple drug binding sites on P-glycoprotein

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Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells

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Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance

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Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

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Derivatives of a Novel Cyclopeptolide. 2. Synthesis, Activity against Multidrug Resistance in CHO and KB Cells in vitro, and Structure-Activity Relationships

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Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer

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7 January 2021

Chemistry and biological activity of new 3-benzazepines

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Identifiers

DOI

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3 August 2017

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