FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo (Q34575984)

3 August 2017

title

FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo (English)

1 reference

3 August 2017

Ana Patiño-García

6

0 references

Roland Schüle

5

object named as

Roland Schüle

1 reference

3 August 2017

Julia Brun

1

1 reference

3 August 2017

François-Xavier Dieudonné

2

1 reference

3 August 2017

Caroline Marty

3

1 reference

3 August 2017

Judith Müller

4

1 reference

3 August 2017

Fernando Lecanda

7

1 reference

3 August 2017

Olivia Fromigué

8

1 reference

3 August 2017

Pierre J Marie

9

1 reference

3 August 2017

language of work or name

English

0 references

publication date

28 January 2013

1 reference

3 August 2017

1 reference

3 August 2017

volume

8

1 reference

3 August 2017

issue

1

1 reference

3 August 2017

page(s)

e55034

1 reference

Creative Commons Attribution 4.0 International

3 August 2017

copyright license

start time

28 January 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells

7 July 2018

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High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells.

7 July 2018

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Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice

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7 July 2018

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7 July 2018

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Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

7 July 2018

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7 July 2018

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Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion

7 July 2018

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FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.

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7 July 2018

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The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation.

7 July 2018

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7 July 2018

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Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

7 July 2018

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Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

7 July 2018

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Functional interaction between beta-catenin and FOXO in oxidative stress signaling

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

1 reference

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Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

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7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

7 July 2018

1 reference

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An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

FHL2, a novel tissue-specific coactivator of the androgen receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Identification of c-MYC as a target of the APC pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

7 July 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0055034

Differently regulated androgen receptor transcriptional complex in prostate cancer compared with normal prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0055034

Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0055034

RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0055034

Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Osteosarcoma and other bone cancers.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557236

Hematogenous micrometastases in osteosarcoma patients

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23383046

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23383046

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0055034

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference