The enemy within: keeping self-reactive T cells at bay in the periphery (Q34573771)

3 August 2017

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title

The enemy within: keeping self-reactive T cells at bay in the periphery (English)

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3 August 2017

2

Abul K Abbas

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3 August 2017

Lucy S K Walker

1

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3 August 2017

publication date

1 January 2002

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

1

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3 August 2017

page(s)

11-19

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A direct estimate of the human alphabeta T cell receptor diversity

3 August 2017

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T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects

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Immunology taught by viruses

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Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

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Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

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CTLA-4 ligation blocks CD28-dependent T cell activation

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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Fingerprints of anergic T cells

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

21 January 2018

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

21 January 2018

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

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The expanding world of co-stimulation: the two-signal model revisited

21 January 2018

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IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis

21 January 2018

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T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

21 January 2018

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Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 bias

21 January 2018

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Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

21 January 2018

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Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

21 January 2018

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Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

21 January 2018

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In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

21 January 2018

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BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.

21 January 2018

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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

21 January 2018

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Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene

21 January 2018

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Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

21 January 2018

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

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Requirement for transforming growth factor beta1 in controlling T cell apoptosis

21 January 2018

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

21 January 2018

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

21 January 2018

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Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis

21 January 2018

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4 T cells

21 January 2018

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Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

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Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

21 January 2018

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RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

21 January 2018

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The immune system evolved to discriminate infectious nonself from noninfectious self

21 January 2018

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

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Toll-like receptors in the induction of the innate immune response

21 January 2018

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

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Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

21 January 2018

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

21 January 2018

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CD4 T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells

21 January 2018

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Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo

21 January 2018

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Natural adjuvants: endogenous activators of dendritic cells

21 January 2018

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Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

21 January 2018

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A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

21 January 2018

1 reference

Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells

21 January 2018

1 reference

Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.

21 January 2018

1 reference

Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

21 January 2018

1 reference

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

21 January 2018

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Suppressor effector function of CD4 CD25 immunoregulatory T cells is antigen nonspecific

21 January 2018

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CD4 CD25 immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

1 reference

B7/CD28 costimulation is essential for the homeostasis of the CD4 CD25 immunoregulatory T cells that control autoimmune diabetes

21 January 2018

1 reference

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25( )CD4( ) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

Immunologic self-tolerance maintained by CD25( )CD4( ) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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A CD4 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

21 January 2018

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Differentiation of regulatory T cells 1 is induced by CD2 costimulation

21 January 2018

1 reference

Induction of interleukin 10-producing, nonproliferating CD4( ) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

21 January 2018

1 reference

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4 T cells

21 January 2018

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

21 January 2018

1 reference

Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes

21 January 2018

1 reference

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

21 January 2018

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Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.

21 January 2018

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Chlamydia infections and heart disease linked through antigenic mimicry

21 January 2018

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Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

21 January 2018

1 reference

Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis

21 January 2018

1 reference

Analysis of the relationship between viral infection and autoimmune disease

21 January 2018

1 reference

Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry

21 January 2018

1 reference

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8 T Cells to Cause Immunopathology

21 January 2018

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Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes.

21 January 2018

1 reference

CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes

21 January 2018

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4( )25( ) immunoregulatory T cells

21 January 2018

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A very high level of crossreactivity is an essential feature of the T-cell receptor

21 January 2018

1 reference

T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes

31 March 2020

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Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

31 March 2020

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Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking

31 March 2020

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Evidence that induction of tolerance in vivo involves active signaling via a B7 ligand-dependent mechanism: CTLA4-Ig protects V beta 8 T cells from tolerance induction by the superantigen staphylococcal enterotoxin B

31 March 2020

1 reference

Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b CD11c dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC

31 March 2020

1 reference

Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

31 March 2020

1 reference

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

31 March 2020

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Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo

31 March 2020

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Tolerance, danger, and the extended family

31 March 2020

1 reference

Naturally anergic and suppressive CD25( )CD4( ) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

31 March 2020

1 reference

Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

31 March 2020

1 reference

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

31 March 2020

1 reference

Natural killer cells determine the outcome of B cell–mediated autoimmunity

31 March 2020

1 reference

Early quantitative and functional deficiency of NK1 -like thymocytes in the NOD mouse

31 March 2020

1 reference

Thymic selection of CD4 CD25 regulatory T cells induced by an agonist self-peptide

31 March 2020

1 reference

Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development

31 March 2020

1 reference

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI701

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3 August 2017

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