Amyloid metabolism and secretases in Alzheimer's disease (Q34566551)

3 August 2017

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title

Amyloid metabolism and secretases in Alzheimer's disease (English)

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3 August 2017

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Xia W

1

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3 August 2017

publication date

1 September 2001

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Current Neurology and Neuroscience Reports

3 August 2017

published in

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3 August 2017

volume

1

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3 August 2017

issue

5

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3 August 2017

page(s)

422-427

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Intraneuronal Abeta42 accumulation in human brain.

3 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007/S11910-001-0101-Z

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

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12 December 2020

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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12 December 2020

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

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12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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12 December 2020

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Maturation and pro-peptide cleavage of beta-secretase

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12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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12 December 2020

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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12 December 2020

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

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12 December 2020

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization

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12 December 2020

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

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12 December 2020

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

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12 December 2020

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

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12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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12 December 2020

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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12 December 2020

A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP

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12 December 2020

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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12 December 2020

Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex

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12 December 2020

Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice.

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12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

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12 December 2020

Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease

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12 December 2020

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

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12 December 2020

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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12 December 2020

10.1007/S11910-001-0101-Z

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1035789010

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