Cellular platforms for HTS: three case studies (Q34563392)

3 August 2017

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title

Cellular platforms for HTS: three case studies (English)

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ORCID Public Data File 2021

3 August 2017

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author name string

Paul A Johnston

series ordinal

1

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3 August 2017

Patricia A Johnston

series ordinal

2

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3 August 2017

publication date

1 March 2002

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3 August 2017

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3 August 2017

volume

7

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3 August 2017

issue

6

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3 August 2017

page(s)

353-363

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Drug discovery: a historical perspective

3 August 2017

cites work

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7 January 2021

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High-throughput and ultra-high-throughput screening: solution- and cell-based approaches

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Technological advances in high-throughput screening

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Cellular assays in HTS.

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Drug screening--beyond the bottleneck

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Screen idols: faster, smaller, cheaper and smarter

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Intracellular detection assays for high-throughput screening

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Cell-based assays and instrumentation for screening ion-channel targets

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Real-time molecular and cellular analysis: the new frontier of drug discovery

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Quantification of G-Protein Coupled Receptor Internatilization Using G-Protein Coupled Receptor-Green Fluorescent Protein Conjugates with the ArrayScantrade mark High-Content Screening System.

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Cytotoxicity tests for high-throughput drug discovery

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High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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7 January 2021

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Development of a high volume screen to identify inhibitors of endothelial cell activation

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Molecular biology of serotonin receptors

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Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily

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Challenges of high throughput screening against cell surface receptors

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Miniaturization of a Mammalian Cell-Based Assay: Luciferase Reporter Gene Readout in a 3 Microliter 1536-Well Plate

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7 January 2021

Measurement of responses from Gi-, Gs-, or Gq-coupled receptors by a multiple response element/cAMP response element-directed reporter assay

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7 January 2021

A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression

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Development of a dual glow-signal firefly and Renilla luciferase assay reagent for the analysis of G-protein coupled receptor signalling

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7 January 2021

Development of a functional reporter gene HTS assay for the identification of mGluR7 modulators

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7 January 2021

Development of a facile method for high throughput screening with reporter gene assays

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A chimeric reporter gene allowing for clone selection and high-throughput screening of reporter cell lines expressing G-protein-coupled receptors

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7 January 2021

Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor

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7 January 2021

Differential activation of transcription factors induced by Ca2 response amplitude and duration

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7 January 2021

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

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7 January 2021

Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells

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Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2 ) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors

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7 January 2021

Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology

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7 January 2021

Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors

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7 January 2021

Noninvasive, real-time method for the examination of thymidine uptake events--application of the method to V-79 cell synchrony studies

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7 January 2021

Measurement of calcium flux through ionotropic glutamate receptors using Cytostar-T scintillating microplates

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7 January 2021

Cytostar-T scintillating microplate assay for measurement of sodium-dependent bile acid uptake in transfected HEK-293 cells

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7 January 2021

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Identifiers

DOI

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3 August 2017

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