The HER family and cancer: emerging molecular mechanisms and therapeutic targets (Q34558080)

3 August 2017

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title

The HER family and cancer: emerging molecular mechanisms and therapeutic targets (English)

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3 August 2017

Natalia V Sergina

1

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3 August 2017

Mark M Moasser

series ordinal

2

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3 August 2017

publication date

5 November 2007

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Trends in Molecular Medicine

3 August 2017

published in

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3 August 2017

volume

13

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3 August 2017

issue

12

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3 August 2017

page(s)

527-534

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Targeting the function of the HER2 oncogene in human cancer therapeutics

3 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

7 July 2018

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Phosphotyrosine interactome of the ErbB-receptor kinase family

7 July 2018

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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

7 July 2018

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7 July 2018

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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

7 July 2018

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Somatic mutations of the ERBB4 kinase domain in human cancers

7 July 2018

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7 July 2018

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Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer

7 July 2018

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Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor

7 July 2018

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

7 July 2018

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Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

7 July 2018

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7 July 2018

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7 July 2018

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

7 July 2018

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7 July 2018

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7 July 2018

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Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

7 July 2018

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Lung cancer: intragenic ERBB2 kinase mutations in tumours

7 July 2018

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

7 July 2018

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

7 July 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

7 July 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

7 July 2018

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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

7 July 2018

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The HER receptor family: a rich target for therapeutic development

7 July 2018

1 reference

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An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

7 July 2018

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The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

7 July 2018

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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

7 July 2018

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

7 July 2018

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ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner

7 July 2018

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Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival

7 July 2018

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The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy

7 July 2018

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Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

7 July 2018

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Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

7 July 2018

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

7 July 2018

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Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

7 July 2018

1 reference

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In vitro activation of Stat3 by epidermal growth factor receptor kinase

7 July 2018

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A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

7 July 2018

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

Ligand-induced activation of A431 cell epidermal growth factor receptors occurs primarily by an autocrine pathway that acts upon receptors on the surface rather than intracellularly

7 July 2018

1 reference

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Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival

7 July 2018

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Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells.

27 October 2018

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Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients

27 October 2018

1 reference

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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

HER2/neu intragenic kinase domain mutations may be major determinant of response to trastuzumab or specific kinase inhibitors in non-small cell lung cancer patients.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

27 October 2018

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Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer.

27 October 2018

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Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.

27 October 2018

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Phase II trial of gefitinib in recurrent glioblastoma

27 October 2018

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Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

27 October 2018

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

27 October 2018

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The single transmembrane domains of ErbB receptors self-associate in cell membranes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035105

Ras activation in human breast cancer

27 October 2018

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ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas

27 October 2018

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12 December 2020

Erlotinib antitumor activity in non-small cell lung cancer models is independent of HER1 and HER2 overexpression

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12 December 2020

A dimerization hierarchy in the transmembrane domains of the HER receptor family

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12 December 2020

Insights from transgenic mouse models of ERBB2-induced breast cancer

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12 December 2020

Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab

1 reference

12 December 2020

10.1016/J.MOLMED.2007.10.002

Identifiers

DOI

1 reference

3 August 2017

1 reference

3 August 2017

1 reference