Inflammation, metaflammation and immunometabolic disorders (Q34550852)

3 August 2017

title

Inflammation, metaflammation and immunometabolic disorders (English)

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3 August 2017

1

Gökhan S Hotamisligil

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3 August 2017

language of work or name

English

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publication date

1 February 2017

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3 August 2017

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3 August 2017

volume

542

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3 August 2017

issue

7640

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3 August 2017

page(s)

177-185

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Inflammation and metabolic disorders

3 August 2017

cites work

1 reference

Metabolic pathways in immune cell activation and quiescence

21 January 2018

1 reference

Homeostasis, inflammation, and disease susceptibility

21 January 2018

1 reference

The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.

21 January 2018

1 reference

The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response

21 January 2018

1 reference

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling

21 January 2018

1 reference

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

21 January 2018

1 reference

Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz.

21 January 2018

1 reference

High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo

21 January 2018

1 reference

Development of diet-induced insulin resistance in adult Drosophila melanogaster.

21 January 2018

1 reference

Studies of insulin resistance in adipocytes induced by macrophage mediator

21 January 2018

1 reference

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

21 January 2018

1 reference

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

21 January 2018

1 reference

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

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Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

21 January 2018

1 reference

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

21 January 2018

1 reference

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

21 January 2018

1 reference

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.

21 January 2018

1 reference

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

1 reference

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

21 January 2018

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The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications.

21 January 2018

1 reference

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

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RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice

21 January 2018

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Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet

21 January 2018

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Novel role of PKR in inflammasome activation and HMGB1 release

21 January 2018

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The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages

21 January 2018

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p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages

21 January 2018

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Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

21 January 2018

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PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

21 January 2018

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Potential role for snoRNAs in PKR activation during metabolic stress

21 January 2018

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Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress

21 January 2018

1 reference

The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

21 January 2018

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PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

21 January 2018

1 reference

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE

21 January 2018

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Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells

21 January 2018

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Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53.

21 January 2018

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Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance

21 January 2018

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

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Normalization of obesity-associated insulin resistance through immunotherapy

21 January 2018

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Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

21 January 2018

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Prostate cancer: 4 big questions.

21 January 2018

1 reference

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

21 January 2018

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B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

21 January 2018

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Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation.

21 January 2018

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Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

21 January 2018

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Adipose invariant natural killer T cells.

21 January 2018

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Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway

21 January 2018

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

21 January 2018

1 reference

Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial

21 January 2018

1 reference

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

21 January 2018

1 reference

MAPK signalling in cellular metabolism: stress or wellness?

21 January 2018

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p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.

21 January 2018

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A central role for JNK in obesity and insulin resistance

21 January 2018

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Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

21 January 2018

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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

21 January 2018

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Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance.

21 January 2018

1 reference

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

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From endoplasmic-reticulum stress to the inflammatory response

21 January 2018

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NOD1 and NOD2 signalling links ER stress with inflammation.

21 January 2018

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Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

21 January 2018

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Endoplasmic reticulum stress in immunity

21 January 2018

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METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

21 January 2018

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Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

21 January 2018

1 reference

Is mitochondrial dysfunction a cause of insulin resistance?

21 January 2018

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

21 January 2018

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Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.

21 January 2018

1 reference

Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice

21 January 2018

1 reference

Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo

21 January 2018

1 reference

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

1 reference

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity

21 January 2018

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The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β

21 January 2018

1 reference

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

21 January 2018

1 reference

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

21 January 2018

1 reference

Inflammation and lipid signaling in the etiology of insulin resistance

21 January 2018

1 reference

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes

21 January 2018

1 reference

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

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Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids

21 January 2018

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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.

21 January 2018

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Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

21 January 2018

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Innate immune receptors: key regulators of metabolic disease progression

21 January 2018

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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

21 January 2018

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Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation

21 January 2018

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Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

21 January 2018

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Ceramides as modulators of cellular and whole-body metabolism

21 January 2018

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Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

21 January 2018

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PKC-theta knockout mice are protected from fat-induced insulin resistance

21 January 2018

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Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity

21 January 2018

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Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε

21 January 2018

1 reference

De Novo Lipogenesis Products and Endogenous Lipokines

21 January 2018

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Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

21 January 2018

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Genomics, Type 2 Diabetes, and Obesity

21 January 2018

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Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

21 January 2018

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Systems biology approach reveals genome to phenome correlation in type 2 diabetes

21 January 2018

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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

21 January 2018

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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

21 January 2018

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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

21 January 2018

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The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

21 January 2018

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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

21 January 2018

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Genetic studies of body mass index yield new insights for obesity biology

21 January 2018

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New genetic loci link adipose and insulin biology to body fat distribution

21 January 2018

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p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients

21 January 2018

1 reference

Genomic and epigenomic regulation of adipose tissue inflammation in obesity

21 January 2018

1 reference

Effects of Tumour Necrosis Factor Antagonists on Insulin Sensitivity/Resistance in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

21 January 2018

1 reference

Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis

21 January 2018

1 reference

Targeting inflammation in the treatment of type 2 diabetes: time to start

21 January 2018

1 reference

Personalized medicine: Time for one-person trials

21 January 2018

1 reference

TNF and EPO: major players in the innate immune response: their discovery

21 January 2018

1 reference

A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice

21 January 2018

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Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control

21 January 2018

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The immunomodulating role of exercise in metabolic disease

21 January 2018

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Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes.

21 January 2018

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Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.

21 January 2018

1 reference

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

21 January 2018

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Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease

21 January 2018

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Obesity is associated with hypothalamic injury in rodents and humans

21 January 2018

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Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

21 January 2018

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A20 controls intestinal homeostasis through cell-specific activities

21 January 2018

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CD40-mediated maintenance of immune homeostasis in the adipose tissue microenvironment.

21 January 2018

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A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

21 January 2018

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Host and Environmental Factors Influencing Individual Human Cytokine Responses

21 January 2018

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Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

21 January 2018

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Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database

21 January 2018

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Insights into obesity and diabetes at the intersection of mouse and human genetics

21 January 2018

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Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity

21 January 2018

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Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion

21 January 2018

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Semaphorins and their receptors in immune cell interactions.

21 January 2018

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Pathological changes in adipose tissue of obese mice

21 January 2018

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7 January 2021

Studies in obese-hyperglycemic mice

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7 January 2021

Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release

1 reference

7 January 2021

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

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7 January 2021

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

1 reference

7 January 2021

Glucose-fatty acid interactions in health and disease

1 reference

7 January 2021

Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation

1 reference

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

7 January 2021

Transitory diabetic syndrome associated with meningococcic meningitis

1 reference

7 January 2021

ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.

1 reference

7 January 2021

A crucial role for adipose tissue p53 in the regulation of insulin resistance

1 reference

7 January 2021

Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity

1 reference

7 January 2021

Hypoglycemic agents and potential anti-inflammatory activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28179656

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NATURE21363

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3 August 2017

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