B cells move to centre stage: novel opportunities for autoimmune disease treatment (Q34544062)

2 August 2017

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title

B cells move to centre stage: novel opportunities for autoimmune disease treatment (English)

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2 August 2017

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Jeffrey L Browning

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publication date

1 July 2006

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Nature Reviews Drug Discovery

2 August 2017

published in

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2 August 2017

volume

5

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2 August 2017

issue

7

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2 August 2017

page(s)

564-576

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Textbook germinal centers?

2 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma

31 March 2020

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31 March 2020

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Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease

31 March 2020

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An APRIL to remember: novel TNF ligands as therapeutic targets

31 March 2020

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Homeostatic niche specification among naïve and activated B cells: a growing role for the BLyS family of receptors and ligands

31 March 2020

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The role of BAFF in immune function and implications for autoimmunity

31 March 2020

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The BAFF/APRIL system: an important player in systemic rheumatic diseases

31 March 2020

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The BAFF/APRIL system: life beyond B lymphocytes.

31 March 2020

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A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys

31 March 2020

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Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects

31 March 2020

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Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54.

31 March 2020

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TACI and BAFF-R mediate isotype switching in B cells

31 March 2020

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TACI is mutant in common variable immunodeficiency and IgA deficiency

31 March 2020

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Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.

31 March 2020

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TACItly changing tunes: farewell to a yin and yang of BAFF receptor and TACI in humoral immunity? New genetic defects in common variable immunodeficiency

31 March 2020

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Microarray-based understanding of normal and malignant plasma cells

31 March 2020

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Reassessing the function of immune-complex retention by follicular dendritic cells

31 March 2020

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T cell-independent somatic hypermutation in murine B cells with an immature phenotype

31 March 2020

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CD40/CD154 interactions at the interface of tolerance and immunity

31 March 2020

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The role of CD40 ligand in systemic lupus erythematosus

31 March 2020

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A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

31 March 2020

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The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus

31 March 2020

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Platelet activation and the CD40/CD40 ligand pathway: mechanisms and implications for human disease

31 March 2020

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CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.

31 March 2020

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Block and tackle: CTLA4Ig takes on lupus

31 March 2020

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TNF/TNFR family members in costimulation of T cell responses

31 March 2020

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Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus

31 March 2020

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Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency.

31 March 2020

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Rationale for interleukin-6 blockade in systemic lupus erythematosus

31 March 2020

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

31 March 2020

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The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody

31 March 2020

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Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

31 March 2020

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

31 March 2020

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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

31 March 2020

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Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

31 March 2020

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Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

31 March 2020

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Toll-like receptor activation in the pathogenesis of systemic lupus erythematosus

31 March 2020

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Type I interferons (alpha/beta) in immunity and autoimmunity

31 March 2020

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Fcgamma receptors: old friends and new family members

31 March 2020

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Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

31 March 2020

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The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G anti-DNA plasma cells

31 March 2020

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Restoration of tolerance in lupus by targeted inhibitory receptor expression

31 March 2020

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Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

31 March 2020

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FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.

31 March 2020

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Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus

31 March 2020

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Complement and its breakdown products in SLE.

31 March 2020

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Therapeutic intravenous immunoglobulins

31 March 2020

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels

31 March 2020

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Acute glomerulonephritis occurring during immunoadsorption with staphylococcal protein A column (Prosorba).

31 March 2020

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Novel Approaches to Therapy for SLE.

31 March 2020

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Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy

31 March 2020

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Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein.

31 March 2020

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Tolerability and safety of rituximab (MabThera).

31 March 2020

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Maintenance of serum antibody levels

31 March 2020

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Challenges in bringing the bench to bedside in drug development for SLE.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2085

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2 August 2017

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