Total synthesis of bryostatin 1 (Q34538229)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

title

Total synthesis of bryostatin 1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

ChEBI release 2020-05-28

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Gary E Keck

1

1 reference

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18 January 2020

Yam B Poudel

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

Thomas J Cummins

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

Jonathan A Covel

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

22 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

number of pages

4

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Journal of the American Chemical Society

inferred from page(s)

published in

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18 January 2020

volume

133

1 reference

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18 January 2020

issue

4

1 reference

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18 January 2020

page(s)

744-747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent

18 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

New approaches to the total synthesis of the bryostatin antitumor macrolides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Synthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Protein kinase C and other diacylglycerol effectors in cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Targeting the cell cycle: a new approach to cancer therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Synthetic studies on the bryostatins: synthetic routes to analogues containing the tricyclic macrolactone core

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

The chemistry and biology of the bryostatin antitumour macrolides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyrans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Protein kinase C and the development of diabetic vascular complications

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Protein kinase C isozymes and the regulation of diverse cell responses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Total Synthesis of Bryostatin 3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells

11 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030632

Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7

11 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21175177

12 December 2020

inferred from PubMed ID database lookup

Olefinic ester and diene ring-closing metathesis using a reduced titanium alkylidene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21175177

12 December 2020

inferred from PubMed ID database lookup

Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21175177

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/JA110198Y

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21175177 AND SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

21175177

1 reference