Disruption of oncogene/tumor suppressor networks during human carcinogenesis (Q34537149)

2 August 2017

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title

Disruption of oncogene/tumor suppressor networks during human carcinogenesis (English)

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2 August 2017

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Karl Münger

1

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2 August 2017

publication date

1 January 2002

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2 August 2017

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2 August 2017

volume

20

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2 August 2017

issue

1

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2 August 2017

page(s)

71-81

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Induction of apoptosis in fibroblasts by c-myc protein

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

The age distribution of cancer and a multi-stage theory of carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Creation of human tumour cells with defined genetic elements

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The multistep nature of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Genetic alterations during colorectal-tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Genomics: journey to the center of biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

A gene expression database for the molecular pharmacology of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

What is Drosophila telling us about cancer?

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Association of adenovirus early-region 1A proteins with cellular polypeptides

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Polyoma virus transforming protein associates with the product of the c-src cellular gene

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The cat and mouse games that genes, viruses, and cells play

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Evolving ideas about cyclins

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The retinoblastoma protein and cell cycle control

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Retinoblastoma protein switches the E2F site from positive to negative element

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The regulation of E2F by pRB-family proteins

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

D11S146 and BCL1 are physically linked but can be discriminated by their amplification status in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Germline p16 mutations in familial melanoma

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

E2F and cell proliferation: a world turned upside down

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Cancer. p53, guardian of the genome

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

pRB plays an essential role in cell cycle arrest induced by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

A model for p53-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

p14ARF links the tumour suppressors RB and p53.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

An alternative pathway for yeast telomere maintenance rescues est1- senescence

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

Myc activates telomerase

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https://api.crossref.org/works/10.1081/CNV-120000369

Direct activation of TERT transcription by c-MYC.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Telomerase activation by the E6 gene product of human papillomavirus type 16.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

Aneuploidy and cancer

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https://api.crossref.org/works/10.1081/CNV-120000369

The clonal evolution of tumor cell populations

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1081/CNV-120000369

Genetic instability and darwinian selection in tumours

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

New link in a web of human genes

21 January 2018

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https://api.crossref.org/works/10.1081/CNV-120000369

21 January 2018

Identifiers

DOI

10.1081/CNV-120000369

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2 August 2017

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