Emerging structure of the nicotinic acetylcholine receptors (Q34522883)

2 August 2017

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title

Emerging structure of the nicotinic acetylcholine receptors (English)

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2 August 2017

Arthur Karlin

1

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2 August 2017

language of work or name

English

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publication date

1 February 2002

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Nature Reviews Neuroscience

2 August 2017

published in

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2 August 2017

volume

3

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2 August 2017

issue

2

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2 August 2017

page(s)

102-114

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On the contraction of muscle, chiefly in relation to the presence of "receptive" substances: Part I

2 August 2017

cites work

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A study of the desensitization produced by acetylcholine at the motor end-plate

31 March 2020

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Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

31 March 2020

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Evolutionary history of the ligand-gated ion-channel superfamily of receptors

31 March 2020

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Evolution of nicotinic acetylcholine receptor subunits

31 March 2020

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Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

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Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye.

31 March 2020

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Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

31 March 2020

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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

31 March 2020

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Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

31 March 2020

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Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

31 March 2020

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Pharmacology and biophysical properties of alpha 7 and alpha 7-alpha 8 alpha-bungarotoxin receptor subtypes immunopurified from the chick optic lobe

31 March 2020

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Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes.

31 March 2020

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Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain

31 March 2020

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Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels

31 March 2020

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alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

31 March 2020

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Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels

31 March 2020

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Nicotinic acetylcholine receptor at 9 A resolution.

31 March 2020

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Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall

31 March 2020

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Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

31 March 2020

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Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

31 March 2020

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Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata.

31 March 2020

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Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor

31 March 2020

1 reference

A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating

31 March 2020

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Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic techniques

31 March 2020

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A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions

31 March 2020

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Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism

31 March 2020

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Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models

31 March 2020

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The dissociation of acetylcholine from open nicotinic receptor channels

31 March 2020

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The impact of receptor desensitization on fast synaptic transmission

31 March 2020

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

31 March 2020

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On the cooperativity of biological membranes

31 March 2020

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On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine

31 March 2020

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Interaction of a semirigid agonist with Torpedo acetylcholine receptor

31 March 2020

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Binding properties of agonists and antagonists to distinct allosteric states of the nicotinic acetylcholine receptor are incompatible with a concerted model

31 March 2020

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

31 March 2020

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A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

31 March 2020

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Location of antigenic determinants on primary sequences of subunits of nicotinic acetylcholine receptor by peptide mapping

31 March 2020

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Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation

31 March 2020

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Affinity labeling of the acetylcholine receptor in the electroplax: electrophoretic separtion in sodium dodecyl sulfate.

31 March 2020

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Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

31 March 2020

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Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations

31 March 2020

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Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

31 March 2020

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Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity

31 March 2020

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Probing the Structure of the Nicotinic Acetylcholine Receptor with 4-Benzoylbenzoylcholine, a Novel Photoaffinity Competitive Antagonist

31 March 2020

1 reference

Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the delta subunit within 0.9 nm of the 5 alpha subunit-binding

31 March 2020

1 reference

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor

31 March 2020

1 reference

Photolabeling reveals the proximity of the alpha-neurotoxin binding site to the M2 helix of the ion channel in the nicotinic acetylcholine receptor.

31 March 2020

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From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

31 March 2020

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Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions

31 March 2020

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Functional Effects on the Acetylcholine Receptor of Multiple Mutations of γAsp174 and δAsp180

31 March 2020

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A mutational analysis of the acetylcholine receptor channel transmitter binding site

31 March 2020

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Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

31 March 2020

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Distinctions in agonist and antagonist specificity conferred by anionic residues of the nicotinic acetylcholine receptor

31 March 2020

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Chemical modification of the active site of the acetylcholine receptor

31 March 2020

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Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist

31 March 2020

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Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

31 March 2020

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Effects of agonists and antagonists on the reactivity of the binding site disulfide in acetylcholine receptor from Torpedo californica

31 March 2020

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Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors.

31 March 2020

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Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

31 March 2020

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Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

31 March 2020

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Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis

31 March 2020

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Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

31 March 2020

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Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor

31 March 2020

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Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function

31 March 2020

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Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity

31 March 2020

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Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants

31 March 2020

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Identification of Equivalent Residues in the γ, δ, and ε Subunits of the Nicotinic Receptor That Contribute to α-Bungarotoxin Binding

31 March 2020

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Affinity labeling of one of two alpha-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

31 March 2020

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Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy

31 March 2020

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Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors

31 March 2020

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Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor

31 March 2020

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Allosteric transitions of the acetylcholine receptor.

31 March 2020

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Chemistry and pharmacology of polypeptide toxins in snake venoms

31 March 2020

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Use of a snake venom toxin to characterize the cholinergic receptor protein

31 March 2020

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Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue

31 March 2020

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Snake venom alpha-neurotoxins and other 'three-finger' proteins

31 March 2020

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Determination of the primary amino acid sequence specifying the alpha-bungarotoxin binding site on the alpha subunit of the acetylcholine receptor from Torpedo californica

31 March 2020

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Mapping of the alpha-bungarotoxin binding site within the alpha subunit of the acetylcholine receptor

31 March 2020

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NMR mapping and secondary structure determination of the major acetylcholine receptor alpha-subunit determinant interacting with alpha-bungarotoxin

31 March 2020

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The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide

31 March 2020

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Variability among the sites by which curaremimetic toxins bind to torpedo acetylcholine receptor, as revealed by identification of the functional residues of alpha-cobratoxin

31 March 2020

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Biotinylation of substituted cysteines in the nicotinic acetylcholine receptor reveals distinct binding modes for alpha-bungarotoxin and erabutoxin a

31 March 2020

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Probing the agonist domain of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis reveals residues in proximity to the alpha-bungarotoxin binding site

31 March 2020

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Structure of the pore-forming transmembrane domain of a ligand-gated ion channel.

31 March 2020

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Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit

31 March 2020

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Contribution of the beta subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor

31 March 2020

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Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit

31 March 2020

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Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the β-Subunit

31 March 2020

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Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications

31 March 2020

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Probing the structure of the nicotinic acetylcholine receptor ion channel with the uncharged photoactivable compound -3H-diazofluorene

31 March 2020

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Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit

31 March 2020

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Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain

31 March 2020

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Structural homology of Torpedo californica acetylcholine receptor subunits

31 March 2020

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Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor

31 March 2020

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Nobel Lecture. Elementary steps in synaptic transmission revealed by currents through single ion channels

31 March 2020

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Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel

31 March 2020

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Computing the field in proteins and channels

31 March 2020

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Energetic optimization of ion conduction rate by the K selectivity filter

31 March 2020

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Chemistry of ion coordination and hydration revealed by a K channel-Fab complex at 2.0 A resolution

31 March 2020

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Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

31 March 2020

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Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

31 March 2020

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A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor

31 March 2020

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Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations

31 March 2020

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Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

31 March 2020

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The location of the gate in the acetylcholine receptor channel

31 March 2020

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Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel

31 March 2020

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Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

31 March 2020

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Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine

31 March 2020

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Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains

31 March 2020

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The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

31 March 2020

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Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

31 March 2020

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State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

31 March 2020

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The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel

31 March 2020

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Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations

31 March 2020

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Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor

31 March 2020

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Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

31 March 2020

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Acetylcholine receptor gating is influenced by the polarity of amino acids at position 9' in the M2 domain

31 March 2020

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Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist

31 March 2020

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The extracellular linker of muscle acetylcholine receptor channels is a gating control element

31 March 2020

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Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

31 March 2020

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Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics

31 March 2020

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Lipid-protein interactions at the nicotinic acetylcholine receptor. A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers.

31 March 2020

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Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome

31 March 2020

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Acetylcholine receptor channel imaged in the open state

31 March 2020

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Voltage clamp analysis of the kinetics of piperidine-induced chloride current in isolated Aplysia neurons

31 March 2020

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Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate alpha7-containing receptor, mediate Cl currents in aplysia neurons.

31 March 2020

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The permeability of endplate channels to monovalent and divalent metal cations

31 March 2020

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Acetylcholine receptor channel ionic selectivity: ions experience an aqueous environment

31 March 2020

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Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia.

31 March 2020

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Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

31 March 2020

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High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor.

31 March 2020

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Tris /Na permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region

31 March 2020

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Asymmetry of the rat acetylcholine receptor subunits in the narrow region of the pore

31 March 2020

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Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily

31 March 2020

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M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective

31 March 2020

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The nicotinic acetylcholine receptor: from molecular model to single-channel conductance.

31 March 2020

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Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

31 March 2020

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Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

31 March 2020

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Substituted-cysteine accessibility method

31 March 2020

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A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

31 March 2020

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Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

31 March 2020

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Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

31 March 2020

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A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherichia coli

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN731

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Dimensions Publication ID

2 August 2017

1042688388

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