Active role for nibrin in the kinetics of atm activation (Q34519762)

2 August 2017

title

Active role for nibrin in the kinetics of atm activation (English)

1 reference

2 August 2017

Patrick Concannon

3

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author name string

Karen Cerosaletti

series ordinal

1

1 reference

2 August 2017

Jocyndra Wright

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 March 2006

1 reference

Molecular and Cellular Biology

2 August 2017

published in

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2 August 2017

volume

26

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2 August 2017

issue

5

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2 August 2017

page(s)

1691-1699

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

2 August 2017

cites work

1 reference

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

7 July 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

7 July 2018

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

7 July 2018

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Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

7 July 2018

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

7 July 2018

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

7 July 2018

1 reference

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

7 July 2018

1 reference

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

7 July 2018

1 reference

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Requirement of the MRN complex for ATM activation by DNA damage

7 July 2018

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7 July 2018

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

7 July 2018

1 reference

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MDC1 is required for the intra-S-phase DNA damage checkpoint

7 July 2018

1 reference

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

7 July 2018

1 reference

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

7 July 2018

1 reference

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Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

7 July 2018

1 reference

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

7 July 2018

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

7 July 2018

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

7 July 2018

1 reference

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Human Rad50/Mre11 is a flexible complex that can tether DNA ends

7 July 2018

1 reference

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Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

7 July 2018

1 reference

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

7 July 2018

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

7 July 2018

1 reference

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

7 July 2018

1 reference

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Enhanced phosphorylation of p53 by ATM in response to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Isolation and characterization of the human MRE11 homologue

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

DNA replication-dependent nuclear dynamics of the Mre11 complex.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430256

10.1128/MCB.26.5.1691-1699.2006

27 October 2018

Identifiers

DOI

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2 August 2017

1 reference

2 August 2017

1 reference