Adapting human pluripotent stem cells to high-throughput and high-content screening (Q34519522)

2 August 2017

title

Adapting human pluripotent stem cells to high-throughput and high-content screening (English)

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2 August 2017

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2

Lorenz Studer

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2 August 2017

Sabrina C Desbordes

1

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2 August 2017

publication date

20 December 2012

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2 August 2017

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2 August 2017

volume

8

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2 August 2017

issue

1

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2 August 2017

page(s)

111-130

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Embryonic stem cell lines derived from human blastocysts

2 August 2017

cites work

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Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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Induced pluripotent stem cell lines derived from human somatic cells

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Reprogramming of human somatic cells to pluripotency with defined factors

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Generation of human induced pluripotent stem cells from dermal fibroblasts

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Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

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Human embryonic stem cell technologies and drug discovery

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Primary cells and stem cells in drug discovery: emerging tools for high-throughput screening

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

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Reprogramming therapeutics: iPS cell prospects for neurodegenerative disease

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Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

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Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.

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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

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Modelling the long QT syndrome with induced pluripotent stem cells

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Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs

21 January 2018

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Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

21 January 2018

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Modelling schizophrenia using human induced pluripotent stem cells

21 January 2018

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LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

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Core transcriptional regulatory circuitry in human embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

21 January 2018

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TGFbeta and SMADs talk to NANOG in human embryonic stem cells

21 January 2018

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MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

21 January 2018

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Feeder-independent culture of human embryonic stem cells

21 January 2018

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IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro.

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A method for the selection of human embryonic stem cell sublines with high replating efficiency after single-cell dissociation.

21 January 2018

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A ROCK inhibitor permits survival of dissociated human embryonic stem cells

21 January 2018

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Attachment and growth of human embryonic stem cells on microcarriers

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Expansion and differentiation of human embryonic stem cells to endoderm progeny in a microcarrier stirred-suspension culture

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Scalable culture and cryopreservation of human embryonic stem cells on microcarriers

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Long-term microcarrier suspension cultures of human embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Automated, scalable culture of human embryonic stem cells in feeder-free conditions.

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.

21 January 2018

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Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion.

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Automated maintenance of embryonic stem cell cultures

21 January 2018

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Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511.

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Synthetic polymer coatings for long-term growth of human embryonic stem cells.

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Controlling destiny through chemistry: small-molecule regulators of cell fate

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Small molecules for stem cells

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

A small molecule primes embryonic stem cells for differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

The future of high-throughput screening

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2012.139

High content screening: seeing is believing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

The beautiful cell: high-content screening in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Pluripotent human stem cells: A novel tool in drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Derivation of midbrain dopamine neurons from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

First steps in establishing a developmental toxicity test method based on human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Spectral karyotyping analysis of human and mouse chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Statistical practice in high-throughput screening data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Experimental design and statistical methods for improved hit detection in high-throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Design and implementation of high-throughput RNAi screens in cultured Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Efficient propagation of single cells accutase-dissociated human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Characterization and culture of human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Facilitated expansion of human embryonic stem cells by single-cell enzymatic dissociation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Successful scale-up of human embryonic stem cell production in a stirred microcarrier culture system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Scalable expansion of human pluripotent stem cells in suspension culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

Human stem cells and drug screening: opportunities and challenges

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2012.139

31 March 2020

Identifiers

DOI

10.1038/NPROT.2012.139

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Dimensions Publication ID

2 August 2017

1023438407

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