Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression. (Q34516142)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21211030 AND SRC:MED&resulttype=core&format=json

19 January 2020

title

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression (English)

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19 January 2020

1

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19 January 2020

Alain Mauviel

6

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19 January 2020

author name string

Leon van Kempen

2

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19 January 2020

Vasileia I Alexaki

3

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19 January 2020

Erwan Le Scolan

4

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19 January 2020

Kunxin Luo

5

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19 January 2020

publication date

6 January 2011

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19 January 2020

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19 January 2020

volume

10

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19 January 2020

issue

1

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19 January 2020

page(s)

2

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TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases

19 January 2020

cites work

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Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer

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7 July 2018

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Regulation of TGF-beta family signaling by E3 ubiquitin ligases

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells

7 July 2018

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

7 July 2018

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Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

7 July 2018

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Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

7 July 2018

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Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover

7 July 2018

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Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

7 July 2018

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Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.

7 July 2018

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Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

7 July 2018

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Large- and small-molecule inhibitors of transforming growth factor-beta signaling.

7 July 2018

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Smad transcription factors

7 July 2018

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Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

7 July 2018

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Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins

7 July 2018

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Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo

7 July 2018

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SKI pathways inducing progression of human melanoma

7 July 2018

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Selective induction of interleukin-8 expression in metastatic melanoma cells by transforming growth factor-beta 1.

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Characterization of Sno expression in malignant melanoma

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

SnoN is a cell type-specific mediator of transforming growth factor-beta responses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Development of TGF-beta signalling inhibitors for cancer therapy

7 July 2018

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SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

7 July 2018

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Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).

7 July 2018

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Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation

7 July 2018

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Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles.

7 July 2018

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Ski and SnoN: negative regulators of TGF-beta signaling

7 July 2018

1 reference

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Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

7 July 2018

1 reference

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Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

7 July 2018

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A multigenic program mediating breast cancer metastasis to bone

7 July 2018

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The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing.

7 July 2018

1 reference

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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Parathyroid hormone-related protein (PTHrP)-(1-139) isoform is efficiently secreted in vitro and enhances breast cancer metastasis to bone in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: functional implications for transforming growth factor beta signaling

7 July 2018

1 reference

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TGF-beta signaling in cancer--a double-edged sword

7 July 2018

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TGF-beta signaling in tumor suppression and cancer progression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Ski/Sno and TGF-beta signaling.

7 July 2018

1 reference

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Arkadia enhances nodal-related signalling to induce mesendoderm

7 July 2018

1 reference

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Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor

7 July 2018

1 reference

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Expression of angiogenic and immunosuppressive factors by uveal melanoma cell lines

7 July 2018

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Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

WAF1, a potential mediator of p53 tumor suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Expression of transforming growth factor-beta 2 in malignant melanoma correlates with the depth of tumor invasion. Implications for tumor progression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Effects of Various Synthetic Retinoids on Proliferation and Immunophenotype of Human Melanoma Cells In Vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

The ski oncogene induces muscle differentiation in quail embryo cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Structure and activities of the ski oncogene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Clinical significance of the expression of c-Ski and SnoN, possible mediators in TGF-beta resistance, in primary cutaneous melanoma

27 October 2018

1 reference

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Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Suppression of tumor metastasis by blockade of transforming growth factor beta signaling in bone marrow cells through a retroviral-mediated gene therapy in mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3025974

Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells.

27 October 2018

1 reference

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

27 October 2018

1 reference

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SKI is critical for repressing the growth inhibitory function of TGF-beta in human melanoma

27 October 2018

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12 December 2020

SKI knockdown inhibits human melanoma tumor growth in vivo

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12 December 2020

Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes

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12 December 2020

Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice

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12 December 2020

Autocrine TGF-beta-regulated expression of adhesion receptors and integrin-linked kinase in HT-144 melanoma cells correlates with their metastatic phenotype

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12 December 2020

Regulation of invasion of epithelial ovarian cancer by transforming growth factor-beta

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12 December 2020

Identifiers

DOI

10.1186/1476-4598-10-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21211030 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21211030 AND SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

21211030

1 reference