Mouse models of Huntington's disease (Q34502714)

2 August 2017

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title

Mouse models of Huntington's disease (English)

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Marie-Françoise Chesselet

2 August 2017

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series ordinal

2

object named as

Marie-Françoise Chesselet

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2 August 2017

Liliana B Menalled

1

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2 August 2017

publication date

1 January 2002

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Trends in Pharmacological Sciences

2 August 2017

published in

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2 August 2017

volume

23

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2 August 2017

issue

1

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2 August 2017

page(s)

32-39

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Neuropathological classification of Huntington's disease

2 August 2017

cites work

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Fourteen and counting: unraveling trinucleotide repeat diseases

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Inactivation of the mouse Huntington's disease gene homolog Hdh

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Mouse Huntington's disease gene homolog (Hdh).

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Intranuclear Neuronal Inclusions: A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases?

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Differential loss of striatal projection neurons in Huntington disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Neurological abnormalities in a knock-in mouse model of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Motor disorder in Huntington's disease begins as a dysfunction in error feedback control.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Replicating Huntington's disease phenotype in experimental animals

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

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https://api.crossref.org/works/10.1016/S0165-6147(00)01884-8

7 January 2021

10.1016/S0165-6147(00)01884-8

Identifiers

DOI

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2 August 2017

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