Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. (Q34500210)

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English	Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.	scientific article

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20 March 2020

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia (English)

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20 March 2020

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cognitive dysfunction

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20 March 2020

Donna M Wilcock

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Donna M Wilcock

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Dana M Niedowicz

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Valerie L Reeves

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Thomas L Platt

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Katharina Kohler

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Tina L Beckett

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David K Powell

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Tiffany L Lee

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Travis R Sexton

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Eun Suk Song

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Lawrence D Brewer

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Caitlin S Latimer

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Kara L Larson

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Sabire Ozcan

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Christopher M Norris

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Louis B Hersh

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20 March 2020

Nada M Porter

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Michael Paul Murphy

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10 June 2014

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20 March 2020

Acta Neuropathologica Communications

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20 March 2020

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20 March 2020

Hippocampal calcium dysregulation at the nexus of diabetes and brain aging

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7 July 2018

Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes

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7 July 2018

Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice.

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7 July 2018

Leptin regulates amyloid β production via the γ-secretase complex

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7 July 2018

Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.

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Alzheimer's disease: pathological mechanisms and recent insights

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Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling

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Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy

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Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice

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γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.

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PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway

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7 July 2018

A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal Models

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Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

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Endothelin-1 and diabetic complications: Focus on the vasculature

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Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle

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Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

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Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model

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Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia

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Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

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Adiposity, type 2 diabetes, and Alzheimer's disease

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7 July 2018

Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.

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Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

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Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease

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gamma-Secretase: a multifaceted regulator of angiogenesis

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Animal models in type 2 diabetes research: an overview.

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Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.

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10.1186/2051-5960-2-64

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20 March 2020

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