Modeling and simulation: tools for metabolic engineering (Q34495082)

2 August 2017

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title

Modeling and simulation: tools for metabolic engineering (English)

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2 August 2017

1

Wolfgang Wiechert

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2 August 2017

publication date

1 March 2002

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2 August 2017

published in

Journal of Biotechnology

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2 August 2017

volume

94

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2 August 2017

issue

1

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2 August 2017

page(s)

37-63

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Genetically structured modeling of protein production in filamentous fungi

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Modeling the regulation of bacterial genes producing proteins that strongly influence growth

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Toward a science of metabolic engineering

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A 'top-down' approach to the determination of control coefficients in metabolic control theory.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Insertion of microscopic objects through plant cell walls using laser microsurgery

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis: steady-state analysis.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Stoichiometric network analysis

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

How will bioinformatics influence metabolic engineering?

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Mechanistic stoichiometry of yeast mitochondrial oxidative phosphorylation

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Optimization of regulatory architectures in metabolic reaction networks.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Proteomics: theoretical and experimental considerations.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A second-order approach to metabolic control analysis.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Quantitative assessment of regulation in metabolic systems

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

10 Phosphofructokinase from yeast

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A universal method for achieving increases in metabolite production

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Control theory of regulatory cascades.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Functional genomic technologies: creating new paradigms for fundamental and applied biology

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic control theory: its role in microbiology and biotechnology

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Identification of regulatory properties of metabolic networks by graph theoretical modeling

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

The organization of metabolic reaction networks: a signal-oriented approach to cellular models.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

The organization of metabolic reaction networks. II. Signal processing in hierarchical structured functional units

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Genetically structured models forlac promoter-operator function in the Escherichia coli chromosome and in multicopy plasmids: Lac operator function.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Genetically structured models for lac promoter-operator function in the chromosome and in multicopy plasmids: Lac promoter function

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

The cell-bag of enzymes or network of channels?

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Computer-aided synthesis of biochemical pathways.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Bidirectional reaction steps in metabolic networks: IV. Optimal design of isotopomer labeling experiments.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic control analysis of biochemical pathways based on a thermokinetic description of reaction rates

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic engineering: techniques for analysis of targets for genetic manipulations

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

METATOOL: for studying metabolic networks.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Pathway kinetics and metabolic control analysis of a high-yielding strain ofPenicillium chrysogenum during fed batch cultivations

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic control theory: a structural approach.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Regulation of intracellular protein turnover: covalent modification as a mechanism of marking proteins for degradation

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae: II. Mathematical model.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

How to recognize monofunctional units in a metabolic system.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Implications of macromolecular crowding for signal transduction and metabolite channeling

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Understanding glucose transport by the bacterial phosphoenolpyruvate:glycose phosphotransferase system on the basis of kinetic measurements in vitro.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Estimation of P-to-O ratio in Bacillus subtilis and its influence on maximum riboflavin yield

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Automated sampling device for monitoring intracellular metabolite dynamics

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

1 reference

7 January 2021

Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Quantitative analysis of metabolic fluxes in Escherichia coli, using two-dimensional NMR spectroscopy and complete isotopomer models.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Modular analysis of the control of complex metabolic pathways.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

MPS: An artificially intelligent software system for the analysis and synthesis of metabolic pathways.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Experimental determination of group flux control coefficients in metabolic networks

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Responses of metabolic systems to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Responses of metabolic systems to large changes in enzyme activities and effectors. 2. The linear treatment of branched pathways and metabolite concentrations. Assessment of the general non-linear case.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: Formulation and verification of a hypothesis.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Network rigidity and metabolic engineering in metabolite overproduction.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic engineering--methodologies and future prospects

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic fluxes and metabolic engineering

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Evidence for orientation-conserved transfer in the TCA cycle in Saccharomyces cerevisiae: 13C NMR studies

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Experimental design for the identification of macrokinetic models and model discrimination

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae : I. Experimental observations

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

E-CELL: software environment for whole-cell simulation

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger: I. Model definition and stability of the steady state

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger: II. Sensitivity analysis

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Optimization of nonlinear biotechnological processes with linear programming: Application to citric acid production by Aspergillus niger.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Metabolic engineering from a cybernetic perspective. 1. Theoretical preliminaries

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Tendency modeling: a new approach to obtain simplified kinetic models of metabolism applied to Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

A comparison of heuristic search algorithms for molecular docking.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments.

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Bidirectional reaction steps in metabolic networks: II. Flux estimation and statistical analysis

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

13C metabolic flux analysis

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations

1 reference

https://api.crossref.org/works/10.1016/S0168-1656(01)00418-7

7 January 2021

10.1016/S0168-1656(01)00418-7

Identifiers

DOI

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2 August 2017

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