Short- and long-term effects of chromosome mis-segregation and aneuploidy (Q34486530)

2 August 2017

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title

Short- and long-term effects of chromosome mis-segregation and aneuploidy (English)

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2 August 2017

2

Angelika Amon

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Stefano Santaguida

object named as

Stefano Santaguida

series ordinal

1

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publication date

1 July 2015

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Nature Reviews Molecular Cell Biology

2 August 2017

published in

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2 August 2017

volume

16

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2 August 2017

issue

8

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2 August 2017

page(s)

473-485

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

2 August 2017

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Aneuploidy: cells losing their balance

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Identification of aneuploidy-tolerating mutations

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Gene expression and distribution of Swi6 in partial aneuploids of the fission yeast Schizosaccharomyces pombe

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Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain

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31 March 2020

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31 March 2020

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Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

31 March 2020

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31 March 2020

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Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes

31 March 2020

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Transcriptional consequences of aneuploidy

31 March 2020

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Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

31 March 2020

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Unique features of the transcriptional response to model aneuploidy in human cells

31 March 2020

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31 March 2020

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Genomic expression programs in the response of yeast cells to environmental changes

31 March 2020

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

31 March 2020

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Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

31 March 2020

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A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis

31 March 2020

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Adapting proteostasis for disease intervention

31 March 2020

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Cellular strategies for controlling protein aggregation

31 March 2020

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Protein folding and misfolding

31 March 2020

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The Yin and Yang of protein folding

31 March 2020

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A role for ubiquitin in selective autophagy

31 March 2020

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Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Growth arrest and chromosome instability in aneuploid yeast.

31 March 2020

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31 March 2020

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Aneuploid yeast strains exhibit defects in cell growth and passage through START

31 March 2020

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

31 March 2020

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Aneuploidy acts both oncogenically and as a tumor suppressor

31 March 2020

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Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

31 March 2020

1 reference

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

31 March 2020

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The landscape of somatic copy-number alteration across human cancers

31 March 2020

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Characterization of MAD2B and other mitotic spindle checkpoint genes

31 March 2020

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Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.

31 March 2020

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Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

31 March 2020

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Loss of pRB causes centromere dysfunction and chromosomal instability

31 March 2020

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pRB, a tumor suppressor with a stabilizing presence

31 March 2020

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Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

31 March 2020

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Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

31 March 2020

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Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

31 March 2020

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Risks of leukaemia and solid tumours in individuals with Down's syndrome.

31 March 2020

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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

31 March 2020

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Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

31 March 2020

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Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia

31 March 2020

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

31 March 2020

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

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Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

31 March 2020

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Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

31 March 2020

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Karyotypic determinants of chromosome instability in aneuploid budding yeast

31 March 2020

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Aneuploidy drives genomic instability in yeast

31 March 2020

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Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor

31 March 2020

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Aneuploidy and isochromosome formation in drug-resistant Candida albicans

31 March 2020

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Chromosomal duplication is a transient evolutionary solution to stress.

31 March 2020

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Targeting the adaptability of heterogeneous aneuploids

31 March 2020

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Signalling dynamics in the spindle checkpoint response

31 March 2020

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Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

31 March 2020

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Does aneuploidy cause cancer?

31 March 2020

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Statistical analysis of nondisjunction assays in Drosophila

31 March 2020

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Nondisjunction of the X chromosomes in females ofDrosophila hydei

31 March 2020

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Recombination and nondisjunction in humans and flies

31 March 2020

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Distribution of aneuploidy in human gametes: comparison between human sperm and oocytes

31 March 2020

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The frequency of aneuploidy among individual chromosomes in 6,821 human sperm chromosome complements

31 March 2020

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Aneuploidy in human spermatozoa.

31 March 2020

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The occurrence of aneuploidy in human: lessons from the cytogenetic studies of human oocytes

31 March 2020

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Gender effects on the incidence of aneuploidy in mammalian germ cells

31 March 2020

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Whole-Chromosome Aneuploidy Analysis in Human Oocytes: Focus on Comparative Genomic Hybridization

31 March 2020

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Human aneuploidy: mechanisms and new insights into an age-old problem

31 March 2020

1 reference

Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity.

31 March 2020

1 reference

12 December 2020

Human aneuploidy: incidence, origin, and etiology

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12 December 2020

Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere

1 reference

12 December 2020

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model

1 reference

12 December 2020

Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae.

1 reference

12 December 2020

The release of labeled amino acids from the proteins of rat liver slices

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12 December 2020

Identifiers

DOI

10.1038/NRM4025

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Dimensions Publication ID

2 August 2017

1003767537

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