53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. (Q34480292)

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17 January 2020

title

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis (English)

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17 January 2020

1

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author name string

Sonia Franco

2

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17 January 2020

Michael M Murphy

3

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17 January 2020

Craig H Bassing

4

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17 January 2020

Kevin D Mills

5

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17 January 2020

Melissa M Adams

6

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17 January 2020

Nicole C Walsh

7

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17 January 2020

John P Manis

8

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17 January 2020

George Z Rassidakis

9

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17 January 2020

Frederick W Alt

10

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17 January 2020

Phillip B Carpenter

11

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17 January 2020

language of work or name

English

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publication date

21 February 2006

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Proceedings of the National Academy of Sciences of the United States of America

17 January 2020

published in

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17 January 2020

volume

103

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issue

9

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page(s)

3310-3315

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53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

DNA repair, genome stability, and aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

53BP1 is required for class switch recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

The generation of antibody diversity through somatic hypermutation and class switch recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

MDC1 is a mediator of the mammalian DNA damage checkpoint

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

The mechanism and regulation of chromosomal V(D)J recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Genomic instability in mice lacking histone H2AX

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Kinetochore localisation of the DNA damage response component 53BP1 during mitosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Multicolour spectral karyotyping of mouse chromosomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Tumor spectrum analysis in p53-mutant mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.0511259103

53BP1 oligomerization is independent of its methylation by PRMT1.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.0511259103

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413919

Effects of genetic background on tumorigenesis in p53-deficient mice

27 October 2018

1 reference

12 December 2020

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

1 reference

12 December 2020

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

1 reference

12 December 2020

53BP1, an activator of ATM in response to DNA damage

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0511259103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16492765 AND SRC:MED&resulttype=core&format=json

17 January 2020

0 references

1 reference

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17 January 2020

PubMed publication ID

16492765

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16492765 AND SRC:MED&resulttype=core&format=json