The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction (Q34468998)

2 August 2017

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title

The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction (English)

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2 August 2017

main subject

neuromuscular junction

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4

Angela Vincent

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2 August 2017

Yohan Liyanage

1

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2 August 2017

Werner Hoch

series ordinal

2

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2 August 2017

David Beeson

series ordinal

3

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2 August 2017

publication date

1 January 2002

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2 August 2017

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2 August 2017

volume

25

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2 August 2017

issue

1

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2 August 2017

page(s)

4-16

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Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold

2 August 2017

cites work

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Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

21 January 2018

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Acetylcholine receptor delta subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita

21 January 2018

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Localization and regulation of MuSK at the neuromuscular junction

21 January 2018

1 reference

Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction

21 January 2018

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Agrin: a synaptic basal lamina protein that regulates development of the neuromuscular junction

21 January 2018

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A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering

21 January 2018

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Distribution of alpha-dystroglycan during embryonic nerve-muscle synaptogenesis.

21 January 2018

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Agrin-Induced Postsynaptic-like Apparatus in Skeletal Muscle Fibersin Vivo

21 January 2018

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Novel functional epsilon-subunit polypeptide generated by a single nucleotide deletion in acetylcholine receptor deficiency congenital myasthenic syndrome

21 January 2018

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Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vitro neuromuscular synaptogenesis

21 January 2018

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The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo

21 January 2018

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An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix

21 January 2018

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Congenital myasthenic syndromes: recent advances

21 January 2018

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21 January 2018

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The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans

21 January 2018

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RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes

21 January 2018

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The postsynaptic 43k protein clusters muscle nicotinic acetylcholine receptors in xenopus oocytes

21 January 2018

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Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

21 January 2018

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Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

21 January 2018

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Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor

21 January 2018

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Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site

21 January 2018

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Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor

21 January 2018

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Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK.

21 January 2018

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Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: Required role for the MuSK ectodomain?

21 January 2018

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Agrin acts via a MuSK receptor complex

21 January 2018

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Comparison of agrin-like proteins from the extracellular matrix of chicken kidney and muscle with neural agrin, a synapse organizing protein

21 January 2018

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Components of Torpedo electric organ and muscle that cause aggregation of acetylcholine receptors on cultured muscle cells

21 January 2018

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Basal lamina components are concentrated in premuscle masses and at early acetylcholine receptor clusters in chick embryo hindlimb muscles

21 January 2018

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Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex

21 January 2018

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Induction of utrophin gene expression by heregulin in skeletal muscle cells: role of the N-box motif and GA binding protein

21 January 2018

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Muscle and Neural Isoforms of Agrin Increase Utrophin Expression in Cultured Myotubes via a Transcriptional Regulatory Mechanism

21 January 2018

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The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling

21 January 2018

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Formation of the neuromuscular junction. Agrin and its unusual receptors

21 January 2018

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Developmental regulation of highly active alternatively spliced forms of agrin

21 January 2018

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Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies

21 January 2018

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A capacitative calcium current in cultured skeletal muscle cells is mediated by the calcium-specific leak channel and inhibited by dihydropyridine compounds

21 January 2018

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Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells

21 January 2018

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Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle

21 January 2018

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Dystrophin is required for organizing large acetylcholine receptor aggregates

21 January 2018

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Acetylcholine receptors and myasthenia

21 January 2018

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Motor neurons contain agrin-like molecules

21 January 2018

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Role for a synapse-specific carbohydrate in agrin-induced clustering of acetylcholine receptors

21 January 2018

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21 January 2018

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Immobilization of nicotinic acetylcholine receptors in mouse C2 myotubes by agrin-induced protein tyrosine phosphorylation

21 January 2018

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Agrin Can Mediate Acetylcholine Receptor Gene Expression in Muscle by Aggregation of Muscle-derived Neuregulins

21 January 2018

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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

21 January 2018

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Myasthenia gravis without acetylcholine-receptor antibody: a distinct disease entity

21 January 2018

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Agrin-induced reorganization of extracellular matrix components on cultured myotubes: relationship to AChR aggregation

21 January 2018

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Identification of agrin, a synaptic organizing protein from Torpedo electric organ

21 January 2018

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43K protein and acetylcholine receptors colocalize during the initial stages of neuromuscular synapse formation in vivo

21 January 2018

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Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme

21 January 2018

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Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutations

21 January 2018

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Association of the postsynaptic 43K protein with newly formed acetylcholine receptor clusters in cultured muscle cells

21 January 2018

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Clustering and immobilization of acetylcholine receptors by the 43-kD protein: a possible role for dystrophin-related protein.

21 January 2018

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Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor

21 January 2018

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Nerve extract induces increase and redistribution of acetylcholine receptors on cloned muscle cells

21 January 2018

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Rapsyn's knobs and holes: eight tetratrico peptide repeats

21 January 2018

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Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn

21 January 2018

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Agrin-like molecules at synaptic sites in normal, denervated, and damaged skeletal muscles

21 January 2018

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Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions.

21 January 2018

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Association of arthrogryposis multiplex congenita with maternal antibodies inhibiting fetal acetylcholine receptor function

21 January 2018

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Neuregulins and erbB receptors at neuromuscular junctions and at agrin-induced postsynaptic-like apparatus in skeletal muscle

21 January 2018

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γ-AChR/ϵ-AChR Switch at Agrin-Induced Postsynaptic-like Apparatus in Skeletal Muscle

21 January 2018

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The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

21 January 2018

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Structure and expression of a rat agrin

21 January 2018

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Development of the vertebrate neuromuscular junction

21 January 2018

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Ultrastructural localization of the Mr 43,000 protein and the acetylcholine receptor in Torpedo postsynaptic membranes using monoclonal antibodies

21 January 2018

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Agrin induces alpha-actinin, filamin, and vinculin to co-localize with AChR clusters on cultured chick myotubes

21 January 2018

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Identification and characterization of 5' extension of mammalian agrin cDNA, the exons and the promoter sequences

21 January 2018

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Aneural muscle cell cultures make synaptic basal lamina components

21 January 2018

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Utrophin abundance is reduced at neuromuscular junctions of patients with both inherited and acquired acetylcholine receptor deficiencies

21 January 2018

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Cell-specific regulation of agrin RNA splicing in the chick ciliary ganglion

21 January 2018

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Laminin-induced Acetylcholine Receptor Clustering: An Alternative Pathway

21 January 2018

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Developmental expression and alternative splicing of chick agrin RNA.

21 January 2018

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PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

21 January 2018

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Identification of a Novel Alternatively Spliced Agrin mRNA That Is Preferentially Expressed in Non-neuronal Cells

21 January 2018

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cDNA that encodes active agrin

21 January 2018

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Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes

21 January 2018

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Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury

21 January 2018

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Congenital myasthenia: end-plate acetylcholine receptors and electrophysiology in five cases

21 January 2018

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Molecular targets for autoimmune and genetic disorders of neuromuscular transmission

21 January 2018

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Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations

21 January 2018

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Seronegative Myasthenia Gravis: Evidence for Plasma Factor(s) Interfering with Acetylcholine Receptor Function

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MUS.1218

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2 August 2017

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