Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism (Q34463784)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json

1 March 2020

review article

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title

Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Gordon A Francis

series ordinal

2

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1 March 2020

publication date

2 February 2015

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Frontiers in Cell and Developmental Biology

1 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json

1 March 2020

volume

3

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1 March 2020

page(s)

3

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Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae

1 March 2020

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Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease

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6 July 2018

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6 July 2018

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Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease

6 July 2018

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Oxidized LDL-induced endolysosomal phospholipidosis and enzymatically modified LDL-induced foam cell formation determine specific lipid species modulation in human macrophages

6 July 2018

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Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase

6 July 2018

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A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease

6 July 2018

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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

6 July 2018

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Oxidized low-density lipoprotein

6 July 2018

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Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments

6 July 2018

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The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes

6 July 2018

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Regulation mechanisms and signaling pathways of autophagy

6 July 2018

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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

6 July 2018

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A gene network regulating lysosomal biogenesis and function

6 July 2018

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ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells.

6 July 2018

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Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells

6 July 2018

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Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder

6 July 2018

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6 July 2018

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Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

6 July 2018

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Role of oxidative modifications in atherosclerosis

6 July 2018

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Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic Lesions

6 July 2018

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The role of microscopy in understanding atherosclerotic lysosomal lipid metabolism

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Uptake of Oxidized LDL by Macrophages Results in Partial Lysosomal Enzyme Inactivation and Relocation

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6 July 2018

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6 July 2018

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6 July 2018

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Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages

6 July 2018

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6 July 2018

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6 July 2018

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On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The morphogenesis and fate of potential and early atherosclerotic lesions in man.

6 July 2018

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Lysosomes of the arterial wall. I. Isolation and subcellular fractionation of cells from normal rabbit aorta

6 July 2018

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Lysosomes of the arterial wall. IV. Cytochemical localization of acid phosphatase and catalase in smooth muscle cells and foam cells from rabbit atheromatous aorta

6 July 2018

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Role of acid lipase in cholesteryl ester accumulation during atherogenesis. Correlation of enzyme activity with acid lipase-containing macrophages in rabbit and human lesions

6 July 2018

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Early atherogenesis in White Carneau pigeons. II. Ultrastructural and cytochemical observations

6 July 2018

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Lipoproteins containing apo B extracted from human aortas. Structure and function

6 July 2018

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Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages

6 July 2018

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Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation

6 July 2018

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Role of lysosomal and cytosolic pH in the regulation of macrophage lysosomal enzyme secretion

6 July 2018

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Macrophage uptake of cholesterol-containing particles derived from LDL and isolated from atherosclerotic lesions

6 July 2018

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Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

6 July 2018

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The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages.

6 July 2018

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Three types of naturally occurring modified lipoproteins induce intracellular lipid accumulation due to lipoprotein aggregation

6 July 2018

1 reference

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Cytosolic pH regulation in mouse macrophages. Proton extrusion by plasma-membrane-localized H( )-ATPase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Defective catabolism of oxidized LDL by J774 murine macrophages

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Lipid accumulation in human aortic smooth muscle cell lysosomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Lipid accumulation in smooth muscle cell lysosomes im primate atherosclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Significance of various cholesterol, ester hydrolases in aorta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Secretion of lysosomal hydrolases by stimulated and nonstimulated macrophages

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Effect of atherosclerosis on lysosomal cholesterol esterase activity in rabbit aorta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis

6 July 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Peroxisome proliferator-activated receptor alpha controls cellular cholesterol trafficking in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Enzyme therapy for lysosomal acid lipase deficiency in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Phospholipids in oxidized low density lipoproteins perturb the ability of macrophages to degrade internalized macromolecules and reduce intracellular cathepsin B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Low density lipoprotein undergoes oxidation within lysosomes in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4313778

Deficiency of an Acid Lipase in Wolman's Disease

27 October 2018

1 reference

https://api.crossref.org/works/10.3389/FCELL.2015.00003

Lysosomes of the arterial wall. II. Subcellular fractionation of aortic cells from rabbits with experimantal atheroma

21 January 2018

1 reference

12 December 2020

Reduction of Atherosclerotic Plaques by Lysosomal Acid Lipase Supplementation

1 reference

12 December 2020

Wolman's disease: Deficiency of E600-resistant acid esterase activity with storage of lipids in lysosomes

1 reference

12 December 2020

Fibronectin stimulates macrophage uptake of low density lipoprotein-heparin-collagen complexes

1 reference

12 December 2020

Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages

1 reference

12 December 2020

Assay, kinetics, and lysosomal localization of an acid cholesteryl esterase in rabbit aortic smooth muscle cells

1 reference

12 December 2020

Recognition and receptor-mediated endocytosis of the lysosomal acid lipase secreted by cultured human fibroblasts

1 reference

12 December 2020

Increased activity of lysosomal enzymes in human atherosclerotic aortas

1 reference

12 December 2020

Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts

1 reference

12 December 2020

Lipoprotein retention--and clues for atheroma regression

1 reference

12 December 2020

Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion

1 reference

12 December 2020

FOXOphagy path to inducing stress resistance and cell survival

1 reference

12 December 2020

Modified low density lipoproteins decrease the activity and expression of lysosomal acid lipase in human endothelial and smooth muscle cells

1 reference

12 December 2020

pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque

1 reference

12 December 2020

Coexistence of oxidized lipids and alpha-tocopherol in all lipoprotein density fractions isolated from advanced human atherosclerotic plaques

1 reference

12 December 2020

The participation of lysosomes in the transformation of smooth muscle cells to foamy cells in the aorta of cholesterol-fed rabbits

1 reference

12 December 2020

Lysosomal acid cholesteryl esterase activity in normal and lipid-laden aortic cells

1 reference

12 December 2020

Characterization of cell populations isolated from aortas of rhesus monkeys with experimental atherosclerosis

1 reference

12 December 2020

Oxysterols and atherosclerosis

1 reference

12 December 2020

Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima

1 reference

12 December 2020

Apolipoprotein B of oxidized LDL accumulates in the lysosomes of macrophages

1 reference

12 December 2020

Identifiers

DOI

10.3389/FCELL.2015.00003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

25699256

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25699256 AND SRC:MED&resulttype=core&format=json