Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease. (Q34461236)

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English	Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16237181 AND SRC:MED&resulttype=core&format=json

8 January 2020

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16237181 AND SRC:MED&resulttype=core&format=json

8 January 2020

Huntington's disease

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Miguel Diaz-Hernandez

1

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8 January 2020

6

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8 January 2020

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8 January 2020

author name string

Jesús Torres-Peraza

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8 January 2020

Alejandro Salvatori-Abarca

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8 January 2020

María A Morán

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8 January 2020

Pilar Gómez-Ramos

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8 January 2020

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1 October 2005

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8 January 2020

Journal of Neuroscience

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8 January 2020

25

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8 January 2020

42

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8 January 2020

9773-9781

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8 January 2020

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An autopsy case with clinically and molecular genetically diagnosed Huntington's disease with only minimal non-specific neuropathological findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine repeats and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-like inclusions in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal induction of the immunoproteasome in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased hippocampal cell proliferation in R6/1 Huntington's mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation and neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced induction of the immunoproteasome by interferon gamma in neurons expressing mutant Huntingtin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathological classification of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: a stereological study using the cavalieri and optical disector methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

More hippocampal neurons in adult mice living in an enriched environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranuclear Neuronal Inclusions: A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Transgenic animals with inducible, targeted gene expression in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16237181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3183-05.2005

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16237181 AND SRC:MED&resulttype=core&format=json

8 January 2020

release_q6flbzet5fcvdeyn555nba7blu

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24 November 2022

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8 January 2020

PubMed publication ID

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8 January 2020

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