Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis. (Q34455116)

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25 February 2020

title

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis (English)

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25 February 2020

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9

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25 February 2020

Ester M Hammond

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25 February 2020

author name string

L Zeng

1

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25 February 2020

A Morinibu

2

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25 February 2020

M Kobayashi

3

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25 February 2020

Y Zhu

4

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25 February 2020

X Wang

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25 February 2020

Y Goto

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25 February 2020

C J Yeom

7

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25 February 2020

T Zhao

8

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25 February 2020

K Shinomiya

10

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25 February 2020

S Itasaka

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25 February 2020

M Yoshimura

12

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25 February 2020

G Guo

13

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25 February 2020

M Hiraoka

15

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25 February 2020

H Harada

16

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25 February 2020

language of work or name

English

0 references

publication date

22 December 2014

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25 February 2020

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25 February 2020

volume

34

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25 February 2020

issue

36

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25 February 2020

page(s)

4758-4766

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Targeting HIF-1 for cancer therapy

25 February 2020

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Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

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High-efficiency transformation of mammalian cells by plasmid DNA

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Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

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The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors

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Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

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Significance of HIF-1-active cells in angiogenesis and radioresistance

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Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo

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The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25531325

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2014.411

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25531325 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 February 2020

1015807488

0 references

1 reference

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