Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes (Q34452028)

2 August 2017

title

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes (English)

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2 August 2017

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Holcomb L

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Gordon MN

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McGowan E

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Yu X

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Benkovic S

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Jantzen P

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Wright K

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Saad I

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Mueller R

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Morgan D

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Sanders S

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Zehr C

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O'Campo K

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Hardy J

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Prada CM

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Eckman C

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Younkin S

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Hsiao K

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Duff K

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language of work or name

English

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publication date

1 January 1998

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volume

4

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issue

1

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page(s)

97-100

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Amyloid, the presenilins and Alzheimer's disease

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cites work

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning

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7 January 2021

Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task

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7 January 2021

Hippocampal morphology and open-field behavior in Mus musculus domesticus and Mus spretus inbred mice

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7 January 2021

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7 January 2021

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Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization

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7 January 2021

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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7 January 2021

Absence of an association between motor coordination and spatial orientation in lurcher mutant mice.

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7 January 2021

Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction

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7 January 2021

Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat.

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7 January 2021

Identifiers

DOI

10.1038/NM0198-097

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2 August 2017

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