Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial (Q34451729)

2 August 2017

title

Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial (English)

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2 August 2017

main subject

phase II clinical trial

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placebo

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Huntington's disease

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author name string

Huntington Study Group Reach2HD Investigators

series ordinal

1

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2 August 2017

publication date

14 November 2014

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2 August 2017

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2 August 2017

volume

14

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2 August 2017

issue

1

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2 August 2017

page(s)

39-47

1 reference

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

2 August 2017

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Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

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PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease

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A novel approach to rapidly prevent age-related cognitive decline

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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A randomized, placebo-controlled trial of latrepirdine in Huntington disease

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A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease

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Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease

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An evidence-based approach in the treatment of Huntington's disease.

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Identifiers

DOI

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2 August 2017

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