Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy (Q34449938)

2 August 2017

title

Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy (English)

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2 August 2017

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1 reference

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Ahmad R Safa

1

1 reference

2 August 2017

language of work or name

English

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publication date

1 January 2013

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Journal of Carcinogenesis & Mutagenesis

2 August 2017

published in

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2 August 2017

volume

Suppl 6

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Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function

2 August 2017

cites work

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c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

6 July 2018

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6 July 2018

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6 July 2018

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Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy

6 July 2018

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Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis.

6 July 2018

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6 July 2018

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Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

6 July 2018

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6 July 2018

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Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

6 July 2018

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Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions

6 July 2018

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6 July 2018

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Regulation of CD95/Fas signaling at the DISC

6 July 2018

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Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis

6 July 2018

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6 July 2018

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Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP.

6 July 2018

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

6 July 2018

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6 July 2018

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shRNA‐mediated silencing of Gli2 gene inhibits proliferation and sensitizes human hepatocellular carcinoma cells towards TRAIL‐induced apoptosis

6 July 2018

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Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model

6 July 2018

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6 July 2018

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6 July 2018

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The Beclin 1 network regulates autophagy and apoptosis

6 July 2018

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β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

6 July 2018

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Autophagy in immunity and inflammation

6 July 2018

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The regulation of autophagy – unanswered questions

6 July 2018

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BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

6 July 2018

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Autophagy and the Integrated Stress Response

6 July 2018

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Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP

6 July 2018

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Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

6 July 2018

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Autophagy in mammalian development and differentiation

6 July 2018

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Apoptogenic factors released from mitochondria

6 July 2018

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Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

6 July 2018

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The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis

6 July 2018

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c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.

6 July 2018

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

6 July 2018

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Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer

6 July 2018

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Cellular and nuclear degradation during apoptosis

6 July 2018

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The double-edged sword of autophagy modulation in cancer

6 July 2018

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Regulation mechanisms and signaling pathways of autophagy

6 July 2018

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6 July 2018

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6 July 2018

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Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs/Akt-mediated cell survival pathway

6 July 2018

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A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

6 July 2018

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PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

6 July 2018

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Bcl-2 family on guard at the ER.

6 July 2018

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Expression and biological significance of c-FLIP in human hepatocellular carcinomas

6 July 2018

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Death effector domain-containing proteins

6 July 2018

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FLIP and the death effector domain family

6 July 2018

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c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

6 July 2018

1 reference

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Executioner caspase-3 and caspase-7 are functionally distinct proteases

6 July 2018

1 reference

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Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIP(L) and MKP-1, thereby antagonizing UV-induced apoptosis

6 July 2018

1 reference

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FLIP as an anti-cancer therapeutic target

6 July 2018

1 reference

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Autophagy fights disease through cellular self-digestion

6 July 2018

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Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

6 July 2018

1 reference

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Autophagy in the Pathogenesis of Disease

6 July 2018

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c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells

6 July 2018

1 reference

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Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

6 July 2018

1 reference

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The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis

6 July 2018

1 reference

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An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

6 July 2018

1 reference

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mTOR-independent translational control of the extrinsic cell death pathway by RalA.

6 July 2018

1 reference

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Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland

6 July 2018

1 reference

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

6 July 2018

1 reference

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Unique and overlapping substrate specificities of caspase-8 and caspase-10.

6 July 2018

1 reference

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Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans

6 July 2018

1 reference

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E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short).

6 July 2018

1 reference

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A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Cellular FLIP (long form) regulates CD8 T cell activation through caspase-8-dependent NF-kappa B activation

6 July 2018

1 reference

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The caspase-8 modulator c-FLIP.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

6 July 2018

Death receptor signaling

1 reference

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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Autophagy in health and disease: a double-edged sword

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

6 July 2018

The flip side of FLIP

1 reference

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The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Development by self-digestion: molecular mechanisms and biological functions of autophagy

6 July 2018

1 reference

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

6 July 2018

1 reference

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

6 July 2018

1 reference

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Cellular FLICE-inhibitory protein: an attractive therapeutic target?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

NF-kappaB signals induce the expression of c-FLIP.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Activation of the NF-kappaB pathway by caspase 8 and its homologs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Two CD95 (APO-1/Fas) signaling pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Inhibition of death receptor signals by cellular FLIP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

6 July 2018

The FLIP Side of Life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

FLIP-mediated autophagy regulation in cell death control

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L).

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Translational regulation of TRAIL sensitivity.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4219646

Increased expression of cFLIP(L) in colonic adenocarcinoma

9 December 2018

1 reference

12 December 2020

Overexpression of cFLIP in head and neck squamous cell carcinoma and its clinicopathologic correlations

1 reference

12 December 2020

Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients

1 reference

12 December 2020

c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome

1 reference

12 December 2020

Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection

1 reference

12 December 2020

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

12 December 2020

Identifiers

DOI

10.4172/2157-2518.S6-003

0 references

PMC publication ID

4219646

1 reference

2 August 2017

1 reference