Intrinsically disordered segments affect protein half-life in the cell and during evolution (Q34438593)

2 August 2017

title

Intrinsically disordered segments affect protein half-life in the cell and during evolution (English)

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2 August 2017

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1

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2 August 2017

2

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2 August 2017

Kai Kruse

3

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Natalia S de Groot

Natalia Sánchez de Groot

5

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Andreas Matouschek

Andreas Matouschek

7

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Martijn A Huynen

Martijn A Huynen

6

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Mohan Madan Babu

9

M Madan Babu

1 reference

2 August 2017

Jörg Gsponer

4

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2 August 2017

Monika Fuxreiter

8

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2 August 2017

language of work or name

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15 September 2014

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2 August 2017

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2 August 2017

volume

8

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2 August 2017

issue

6

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2 August 2017

page(s)

1832-1844

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Classification of intrinsically disordered regions and proteins

2 August 2017

cites work

1 reference

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Protein synthesis rate is the predominant regulator of protein expression during differentiation

6 July 2018

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The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

6 July 2018

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Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

6 July 2018

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Encoding and decoding cellular information through signaling dynamics

6 July 2018

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The N-terminal region of Nurr1 (a.a 1-31) is essential for its efficient degradation by the ubiquitin proteasome pathway

6 July 2018

1 reference

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The repertoires of ubiquitinating and deubiquitinating enzymes in eukaryotic genomes

6 July 2018

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Protein TAILS: when termini tell tales of proteolysis and function

6 July 2018

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Describing sequence-ensemble relationships for intrinsically disordered proteins

6 July 2018

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The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini.

6 July 2018

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6 July 2018

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Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Proteasome function is required for biological timing throughout the twenty-four hour cycle

6 July 2018

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Intrinsically disordered proteins: regulation and disease

6 July 2018

1 reference

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Dependence of Proteasome Processing Rate on Substrate Unfolding

6 July 2018

1 reference

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Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini

6 July 2018

1 reference

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Rad23 escapes degradation because it lacks a proteasome initiation region

6 July 2018

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PEST motif sequence regulating human NANOG for proteasomal degradation.

6 July 2018

1 reference

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Defining the geometry of the two-component proteasome degron

6 July 2018

1 reference

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6 July 2018

Proteasome Activators

1 reference

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Proteasomes in immune cells: more than peptide producers?

6 July 2018

1 reference

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Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates

6 July 2018

1 reference

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The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway

6 July 2018

1 reference

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A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation

6 July 2018

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Breaking the chains: structure and function of the deubiquitinases

6 July 2018

1 reference

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6 July 2018

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Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

6 July 2018

1 reference

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6 July 2018

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6 July 2018

1 reference

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6 July 2018

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6 July 2018

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Structural disorder serves as a weak signal for intracellular protein degradation.

6 July 2018

1 reference

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The effects of molecular noise and size control on variability in the budding yeast cell cycle

6 July 2018

1 reference

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Proteasome substrate degradation requires association plus extended peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Quantification of protein half-lives in the budding yeast proteome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Genome-wide analysis of mammalian promoter architecture and evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Exploiting heterogeneous sequence properties improves prediction of protein disorder.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Instability of Hes7 protein is crucial for the somite segmentation clock

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome substrate processing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Protein degradation and protection against misfolded or damaged proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Intrinsically unstructured proteins evolve by repeat expansion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Endoproteolytic activity of the proteasome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Regulation of p53 in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I kappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Molecular evidence for an ancient duplication of the entire yeast genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Slipped-strand mispairing: a major mechanism for DNA sequence evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Basic local alignment search tool

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Long indels are disordered: a study of disorder and indels in homologous eukaryotic proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Intrinsic Disorder in Ubiquitination Substrates

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

The N-Terminal Unstructured Domain of Yeast ODC Functions as a Transplantable and Replaceable Ubiquitin-Independent Degron

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

The nanny model for IDPs.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

An unstructured initiation site is required for efficient proteasome-mediated degradation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4358326

Proteasome-mediated protein processing by bidirectional degradation initiated from an internal site

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25220455

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25220455

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural biology. Versatility from protein disorder

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25220455

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.07.055

1 reference

2 August 2017

1 reference

2 August 2017

1 reference