Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling (Q34429013)

2 August 2017

title

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling (English)

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2 August 2017

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Lin Luo

1

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Adam Alexander Wall

Adam A Wall

2

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Kaiwen W Chen

Kaiwen W Chen

7

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Simone M Schoenwaelder

Simone Schoenwaelder

6

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Brendan J. Jenkins

Brendan J Jenkins

9

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Brett M. Collins

Brett M Collins

12

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Kate Schroder

Kate Schroder

11

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Jennifer Stow

Jennifer L Stow

14

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Matthew J. Sweet

Matthew J Sweet

13

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Elizabeth L. Hartland

Elizabeth L Hartland

10

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Shaun P Jackson

Shaun Jackson

8

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author name string

Jeremy C Yeo

3

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2 August 2017

Nicholas D Condon

4

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2 August 2017

Suzanne J Norwood

5

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2 August 2017

publication date

15 July 2014

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2 August 2017

published in

Nature Communications

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2 August 2017

volume

5

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2 August 2017

page(s)

4407

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Intracellular trafficking and secretion of inflammatory cytokines

2 August 2017

cites work

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Toll-like receptor signalling

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CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

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Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.

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The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole

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PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

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Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

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Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

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7 January 2021

Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy

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7 January 2021

Regulation of bone-marrow macrophage proliferation

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7 January 2021

High-throughput quantification of early stages of phagocytosis

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7 January 2021

Identifiers

DOI

10.1038/NCOMMS5407

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Dimensions Publication ID

2 August 2017

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1042488076

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