Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice (Q34428464)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028874 AND SRC:MED&resulttype=core&format=json

9 March 2020

title

Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice (English)

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2

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9 March 2020

author name string

Amit Varma

1

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9 March 2020

Nicholas N Hoke

3

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David E Durrant

4

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Fadi N Salloum

5

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9 March 2020

Rakesh C Kukreja

6

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language of work or name

English

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publication date

21 September 2012

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9 March 2020

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volume

7

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issue

9

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page(s)

e45243

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Creative Commons Attribution 4.0 International

9 March 2020

copyright license

start time

21 September 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.

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Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.

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Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

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Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

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6 July 2018

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Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors

6 July 2018

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Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus

6 July 2018

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6 July 2018

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Sildenafil and vardenafil but not nitroglycerin limit myocardial infarction through opening of mitochondrial K(ATP) channels when administered at reperfusion following ischemia in rabbits

6 July 2018

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Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study

6 July 2018

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Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity

6 July 2018

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The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease

6 July 2018

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6 July 2018

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

6 July 2018

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Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus

6 July 2018

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Tadalafil alters energy metabolism in C2C12 skeletal muscle cells

27 October 2018

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Daily Use of Sildenafil Improves Endothelial Function in Men With Type 2 Diabetes

27 October 2018

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Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis

27 October 2018

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Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

27 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448606

Chronic administration of Sildenafil improves markers of endothelial function in men with Type 2 diabetes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448606

Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice

27 October 2018

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27 October 2018

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Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits

27 October 2018

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Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes

27 October 2018

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Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance

27 October 2018

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Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

27 October 2018

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Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts

27 October 2018

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Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice.

27 October 2018

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Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448606

Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes

27 October 2018

1 reference

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Aldose reductase activation is a key component of myocardial response to ischemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448606

Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase

27 October 2018

1 reference

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Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance

27 October 2018

1 reference

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Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures.

27 October 2018

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Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats.

27 October 2018

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Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology

27 October 2018

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12 December 2020

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

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12 December 2020

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

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12 December 2020

Sildenafil improves diabetic vascular activity through suppressing endothelin receptor A, iNOS and NADPH oxidase which is comparable with the endothelin receptor antagonist CPU0213 in STZ-injected rats

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12 December 2020

Relationship of glycation, antioxidant status and oxidative stress to vascular endothelial damage in diabetes

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Diabetes, a New Mutation in the Mouse

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High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

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Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent

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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

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12 December 2020

10.1371/JOURNAL.PONE.0045243

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028874 AND SRC:MED&resulttype=core&format=json

9 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028874 AND SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

23028874

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028874 AND SRC:MED&resulttype=core&format=json