Therapeutic interventions in sepsis: current and anticipated pharmacological agents (Q34427050)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977655 AND SRC:MED&resulttype=core&format=json

21 March 2020

title

Therapeutic interventions in sepsis: current and anticipated pharmacological agents (English)

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21 March 2020

0 references

1

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21 March 2020

author name string

G Madhava Rao

2

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21 March 2020

Gitu Pandey

3

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21 March 2020

Shweta Sharma

4

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21 March 2020

Naresh Mittapelly

5

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21 March 2020

Ranjita Shegokar

6

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21 March 2020

Prabhat Ranjan Mishra

7

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21 March 2020

language of work or name

English

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publication date

5 September 2014

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British Journal of Pharmacology

21 March 2020

published in

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21 March 2020

volume

171

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21 March 2020

issue

22

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21 March 2020

page(s)

5011-5031

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Why have clinical trials in sepsis failed?

21 March 2020

cites work

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Sepsis: going to the heart of the matter

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Reversal of long-term sepsis-induced immunosuppression by dendritic cells.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock

6 July 2018

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6 July 2018

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Lactoferrin—a multifunctional protein with antimicrobial properties

6 July 2018

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Macrophage migration inhibitory factor: a regulator of innate immunity

6 July 2018

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6 July 2018

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Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors.

6 July 2018

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Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

6 July 2018

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TLR4 as the mammalian endotoxin sensor

6 July 2018

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Risks and benefits of activated protein C treatment for severe sepsis

6 July 2018

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Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

6 July 2018

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Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation

6 July 2018

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Lactoferrin inhibits the lipopolysaccharide-induced expression and proteoglycan-binding ability of interleukin-8 in human endothelial cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Hepatic response to sepsis: interaction between coagulation and inflammatory processes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

The endothelium in sepsis: source of and a target for inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Efficacy and safety of recombinant human activated protein C for severe sepsis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

The importance of antibiotic pharmacokinetics in critical illness

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin-6 response in human monocytic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Protective effects of lithium: a new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis

6 July 2018

1 reference

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

21 January 2018

1 reference

Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock

21 January 2018

1 reference

Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis

21 January 2018

1 reference

In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway

21 January 2018

1 reference

Protective effects of C5a blockade in sepsis

21 January 2018

1 reference

Reduction in mortality associated with statin therapy in patients with severe sepsis

21 January 2018

1 reference

Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.

21 January 2018

1 reference

Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol

21 January 2018

1 reference

Effects of Cl2MDP-encapsulating liposomes in a murine model of Pseudomonas aeruginosa-induced sepsis

21 January 2018

1 reference

The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis

21 January 2018

1 reference

Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways.

21 January 2018

1 reference

Cationic nanoemulsions bearing ciprofloxacin surf-plexes enhances its therapeutic efficacy in conditions of E. coli induced peritonitis and sepsis.

21 January 2018

1 reference

A synthetic peptide derived from bactericidal/permeability-increasing protein neutralizes endotoxin in vitro and in vivo

21 January 2018

1 reference

Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells

21 January 2018

1 reference

Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study

21 January 2018

1 reference

Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils

21 January 2018

1 reference

Metabolomic analysis of thermally injured and/or septic rats

21 January 2018

1 reference

all-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression.

21 January 2018

1 reference

Can nicotine treat sepsis?

21 January 2018

1 reference

Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.

21 January 2018

1 reference

Association between use of lung-protective ventilation with lower tidal volumes and risk of acute lung injury, mortality, pulmonary infection, and atelectasis: a meta-analysis.

21 January 2018

1 reference

Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress

21 January 2018

1 reference

Mifepristone (RU486) restores humoral and T cell-mediated immune response in endotoxin immunosuppressed mice.

21 January 2018

1 reference

Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice

21 January 2018

1 reference

Regulatory role of C5a on macrophage migration inhibitory factor release from neutrophils

21 January 2018

1 reference

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.

21 January 2018

1 reference

Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation

21 January 2018

1 reference

Attenuated effects of chitosan-capped gold nanoparticles on LPS-induced toxicity in laboratory rats

21 January 2018

1 reference

PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia

21 January 2018

1 reference

A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis.

21 January 2018

1 reference

Trial watch: Sepsis study failure highlights need for trial design rethink

21 January 2018

1 reference

A Limulus anti-LPS factor-derived peptide modulates cytokine gene expression and promotes resolution of bacterial acute infection in mice

21 January 2018

1 reference

Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock

21 January 2018

1 reference

Polyketal copolymers: a new acid-sensitive delivery vehicle for treating acute inflammatory diseases

21 January 2018

1 reference

A synthesized cationic tetradecapeptide from hornet venom kills bacteria and neutralizes lipopolysaccharide in vivo and in vitro

21 January 2018

1 reference

Curcumin mediated epigenetic modulation inhibits TREM-1 expression in response to lipopolysaccharide.

21 January 2018

1 reference

Liposomal atp or NAD protects human endothelial cells from energy failure in a cell culture model of sepsis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253453

A metabolomic approach for diagnosis of experimental sepsis

27 October 2018

1 reference

Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion

21 January 2018

1 reference

12 December 2020

Prophylaxis against lipopolysaccharide-induced lung injuries by liposome-entrapped dexamethasone in rats

1 reference

12 December 2020

Selective inhibition of NF-kB activation and TNF-alpha production in macrophages by red blood cell-mediated delivery of dexamethasone

1 reference

12 December 2020

Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties

1 reference

12 December 2020

In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats

1 reference

12 December 2020

Netting bacteria in sepsis

1 reference

12 December 2020

Pathophysiology of sepsis

1 reference

12 December 2020

Translational research in the development of novel sepsis therapeutics: logical deductive reasoning or mission impossible?

1 reference

12 December 2020

An investigation on the approach to target lipopolysaccharide through polymeric capped nano-structured formulation for the management of sepsis

1 reference

12 December 2020

Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway

1 reference

12 December 2020

For sepsis, the drugs don't work

1 reference

12 December 2020

Trial failure prompts soul-searching for critical-care specialists

1 reference

12 December 2020

[Release of HMGB1 by LPS-treated cardiac fibroblasts and its contribution to the production of collagen type I and III]

1 reference

12 December 2020

Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice

1 reference

12 December 2020

Anti-inflammatory activities of isorhamnetin-3-O-galactoside against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice

1 reference

12 December 2020

Anti-inflammatory potential of curcumin and quercetin in rats: role of oxidative stress, heme oxygenase-1 and TNF-α

1 reference

12 December 2020

Continuous hemodiafiltration with a cytokine-adsorbing hemofilter for sepsis

1 reference

12 December 2020

Failure of treatments based on the cytokine storm theory of sepsis: time for a novel approach

1 reference

12 December 2020

Intravenous lipid emulsions: removal mechanisms as compared to chylomicrons

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.12829

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977655 AND SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977655 AND SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

24977655

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977655 AND SRC:MED&resulttype=core&format=json