IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. (Q34420821)

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16 January 2020

title

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells (English)

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Patrick Caplazi

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Cecile King

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Stuart Tangye

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Nico Ghilardi

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author name string

Marcel Batten

1

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Nandhini Ramamoorthi

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Noelyn M Kljavin

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16 January 2020

Jennifer H Cox

5

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Hart S Dengler

6

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16 January 2020

Dimitry M Danilenko

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Melanie Wong

9

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David A Fulcher

10

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Matthew C Cook

11

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Frederic J de Sauvage

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language of work or name

English

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publication date

22 November 2010

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Journal of Experimental Medicine

16 January 2020

published in

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volume

207

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16 January 2020

issue

13

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16 January 2020

page(s)

2895-2906

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Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

16 January 2020

cites work

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

6 July 2018

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

6 July 2018

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Lineage specification and heterogeneity of T follicular helper cells

6 July 2018

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New insights into the differentiation and function of T follicular helper cells.

6 July 2018

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Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells

6 July 2018

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Bcl6 mediates the development of T follicular helper cells

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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

6 July 2018

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Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

6 July 2018

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Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus

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B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus

6 July 2018

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

6 July 2018

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Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

6 July 2018

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Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

6 July 2018

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

6 July 2018

1 reference

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

6 July 2018

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ICOS controls the pool size of effector-memory and regulatory T cells.

6 July 2018

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Deficiency of the type I interferon receptor protects mice from experimental lupus

6 July 2018

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IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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21 January 2018

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21 January 2018

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Loss of IL-7 receptor alpha on CD4 T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue

21 January 2018

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Early commitment of naïve human CD4( ) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

21 January 2018

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Human germinal center T cells are unique Th cells with high propensity for apoptosis induction

21 January 2018

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IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages

21 January 2018

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IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression.

21 January 2018

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Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12.

21 January 2018

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Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

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The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

21 January 2018

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Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells

21 January 2018

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12 December 2020

IL-27 induces a Th1 immune response and susceptibility to experimental arthritis

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12 December 2020

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

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12 December 2020

Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4 T cell reactivity

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12 December 2020

The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4 and CD8 T cells

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12 December 2020

Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1084/JEM.20100064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21098093 AND SRC:MED&resulttype=core&format=json

16 January 2020

0 references

1 reference

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16 January 2020

PubMed publication ID

21098093

1 reference