An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin (Q34418371)

2 August 2017

title

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin (English)

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2 August 2017

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R J Riley

1

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2 August 2017

J L Maggs

2

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2 August 2017

C Lambert

3

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2 August 2017

N R Kitteringham

4

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2 August 2017

B K Park

5

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2 August 2017

language of work or name

English

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publication date

1 November 1988

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British Journal of Clinical Pharmacology

2 August 2017

published in

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2 August 2017

volume

26

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2 August 2017

issue

5

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2 August 2017

page(s)

577-588

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Protein measurement with the Folin phenol reagent

2 August 2017

cites work

1 reference

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Drug metabolism in human liver in vitro: establishment of a human liver bank.

6 July 2018

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In vitro assessment of pharmacogenetic susceptibility to toxic drug metabolites in humans.

6 July 2018

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Mechanisms of toxic injury

6 July 2018

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Evidence for an arene oxide-NIH shift pathway in the metabolic conversion of phenytoin to 5-(4-hydroxyphenyl)-5-phenylhydantoin in the rat and in man.

6 July 2018

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Phenytoin metabolism in mice

6 July 2018

1 reference

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Hepatic epoxide hydrase. Structure-activity relations for substrates and inhibitors

6 July 2018

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Diphenylhydantoin--induced hepatic necrosis

6 July 2018

1 reference

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Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics

6 July 2018

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Enzymatic activation of chemicals to toxic metabolites.

6 July 2018

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The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase mu

6 July 2018

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The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites

6 July 2018

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Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part I.

6 July 2018

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6 July 2018

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A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes

6 July 2018

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Studies on 5,5-diphenylhydantoin irreversible binding to rat liver microsomal proteins

6 July 2018

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Crossref

https://api.crossref.org/works/10.1111/J.1365-2125.1988.TB05298.X

Thrombocytopenia and leucopenia with mianserin-dependent antibodies

21 January 2018

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Acetaminophen toxicity in human lymphocytes in vitro

21 January 2018

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The microsomal metabolism and site of covalent binding to protein of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen.

27 October 2018

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Role of detoxifying enzymes in bromobenzene-induced liver necrosis

27 October 2018

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12 December 2020

Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue

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12 December 2020

The metabolism of mianserin in women, rabbits, and rats: identification of the major urinary metabolites

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12 December 2020

Predisposition to phenytoin hepatotoxicity assessed in vitro

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12 December 2020

Metabolic activation and cytotoxicity of cyclophosphamide in primary cultures of postnatal rat hepatocytes

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12 December 2020

Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system

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12 December 2020

Differential substrate selectivity of murine hepatic cytosolic and microsomal epoxide hydrolases

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12 December 2020

Measurement and characterization of membrane-bound and soluble epoxide hydrolase activities in resting mononuclear leukocytes from human blood

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12 December 2020

Oxygen-18 incorporation studies of the metabolism of phenytoin to the catechol

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12 December 2020

Cytosolic glutathione S-transferases in various rat tissues differ in stereoselectivity with polycyclic arene and alkene oxide substrates

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12 December 2020

Metabolic basis of adverse drug reactions

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12 December 2020

Pharmacological inhibition of aldose reductase in human diabetic neuropathy

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12 December 2020

The debrisoquin hydroxylation phenotype does not predict the metabolism of phenytoin

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12 December 2020

The detection of cytotoxicity produced by short-lived reactive intermediates: a study with bromobenzene

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12 December 2020

Drug-protein conjugates--XVI. Studies of sorbinil metabolism: formation of 2-hydroxysorbinil and unstable protein conjugates

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12 December 2020

Immunological abnormalities and hydantoins

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12 December 2020

10.1111/J.1365-2125.1988.TB05298.X

Identifiers

DOI

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2 August 2017

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2 August 2017

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