Cellular senescence, cancer and aging: the telomere connection (Q34416433)

2 August 2017

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title

Cellular senescence, cancer and aging: the telomere connection (English)

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2 August 2017

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Campisi J

1

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2 August 2017

Kim SH

series ordinal

2

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2 August 2017

Lim CS

series ordinal

3

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2 August 2017

Rubio M

series ordinal

4

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2 August 2017

publication date

1 November 2001

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2 August 2017

published in

Experimental Gerontology

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2 August 2017

volume

36

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2 August 2017

issue

10

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2 August 2017

page(s)

1619-1637

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Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Cancer: the rise of the genetic paradigm

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Structure and function of telomeres

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

1 reference

7 January 2021

Telomere states and cell fates

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase regulation during entry into the cell cycle in normal human T cells

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Genetic instability and darwinian selection in tumours

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Replicative senescence: an old lives' tale?

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Aging and cancer: the double-edged sword of replicative senescence

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

From cells to organisms: can we learn about aging from cells in culture?

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere length and replicative aging in human vascular tissues

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Replicative senescence and cell immortality: the role of telomeres and telomerase

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

A human telomeric protein

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Mammalian telomeres and telomerase

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere length regulation during postnatal development and ageing in Mus spretus

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

1 reference

7 January 2021

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Turning telomeres off and on.

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere maintenance by recombination in human cells.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

1 reference

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Genome changes and gene expression in human solid tumors

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere length regulation

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Mammalian telomeres end in a large duplex loop

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Creation of human tumour cells with defined genetic elements

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Impaired germinal center reaction in mice with short telomeres.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Multiple pathways for the regulation of telomerase activity

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Ku is associated with the telomere in mammals

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Ku acts in a unique way at the mammalian telomere to prevent end joining

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Frequent clones of p53-mutated keratinocytes in normal human skin

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Human is a unique species among primates in terms of telomere length.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

1 reference

7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere biology in human aging and aging syndromes

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Molecular interaction map of the mammalian cell cycle control and DNA repair systems

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

CELL BIOLOGY: Enhanced: Telomere Capping--One Strand Fits All

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

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https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere end-replication problem and cell aging

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Identification of human Rap1: implications for telomere evolution

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase and chromosome end maintenance.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Genes involved in senescence and immortalization

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomeres and their control

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Gerontology as oncology. Research on aging as the key to the understanding of cancer

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

A telomerase component is defective in the human disease dyskeratosis congenita

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

t-loops at trypanosome telomeres.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

The telomerase reverse transcriptase: components and regulation

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

The influence of the microenvironment on the malignant phenotype

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Developmental and tissue-specific regulation of mouse telomerase and telomere length

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

A survey of telomerase activity in human cancer

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Cellular senescence: mitotic clock or culture shock?

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomerase and telomere-binding proteins: controlling the endgame.

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Tankyrase promotes telomere elongation in human cells

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Replicative senescence: implications for in vivo aging and tumor suppression

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Interaction of human Ku70 with TRF2

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

The DNA structures at the ends of eukaryotic chromosomes

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Regulated expression of telomerase activity in human T lymphocyte development and activation

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Human endothelial cell life extension by telomerase expression

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

1 reference

https://api.crossref.org/works/10.1016/S0531-5565(01)00160-7

7 January 2021

10.1016/S0531-5565(01)00160-7

Identifiers

DOI

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2 August 2017

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