Cancer suppression by the chromosome custodians, BRCA1 and BRCA2. (Q34412496)

2 August 2017

title

Cancer suppression by the chromosome custodians, BRCA1 and BRCA2. (English)

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2 August 2017

Ashok R Venkitaraman

1

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2 August 2017

language of work or name

English

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publication date

1 March 2014

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2 August 2017

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2 August 2017

volume

343

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2 August 2017

issue

6178

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2 August 2017

page(s)

1470-1475

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Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Involvement of Brca2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

In search of the tumour-suppressor functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The importance of repairing stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Brca1 controls homology-directed DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Signatures of mutational processes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

53BP1 regulates DSB repair using Rif1 to control 5' end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRC repeats are conserved in mammalian BRCA2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Internal repeats in the BRCA2 protein sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Purified human BRCA2 stimulates RAD51-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Network modeling links breast cancer susceptibility and centrosome dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Cancer risks in BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Variation in cancer risks, by mutation position, in BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Repeated observation of breast tumor subtypes in independent gene expression data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 regulates human mammary stem/progenitor cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Results of a phase II open-label, non-randomized trial of cisplatin chemotherapy in patients with BRCA1-positive metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Resistance to therapy caused by intragenic deletion in BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1252230

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1252230

1 reference

2 August 2017

1 reference