Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential (Q34409278)

2 August 2017

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title

Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential (English)

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2 August 2017

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2

Klaus Lieb

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2 August 2017

1

Inga Herpfer

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2 August 2017

publication date

1 January 2005

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2 August 2017

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2 August 2017

volume

19

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2 August 2017

issue

4

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2 August 2017

page(s)

275-293

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Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1 ) receptor in assays for antidepressant and anxiolytic drugs

2 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.2165/00023210-200519040-00001

Stimulation of ACTH/Cortisol by Intravenously Infused Substance P in Normal Men: Inhibition by Sodium Valproate

21 January 2018

1 reference

12 December 2020

Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus

1 reference

12 December 2020

Roles of substance P and NK(1) receptor in the brainstem in the development of emesis

1 reference

12 December 2020

Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs

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12 December 2020

Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex

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12 December 2020

Cellular mechanisms of neurogenic inflammation

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12 December 2020

Effects of subchronic treatment with imipramine, zimelidine and alaproclate on regional tissue levels of substance P-and neurokinin a/neurokinin B-like immunoreactivity in the brain and spinal cord of the rat

1 reference

12 December 2020

Selective blockade of neurokinin (NK)(1) receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats

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12 December 2020

Immunoreactive substance P and serotonin present in the same dense-core vesicles

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12 December 2020

Exocytosis from large dense cored vesicles as a mechanism for neuropeptide release in the peripheral and central nervous system

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12 December 2020

Modulation of chemotropism in the developing spinal cord by substance P

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12 December 2020

Substance P injection into the dorsal raphe increases blood pressure and serotonin release in hippocampus of conscious rats

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12 December 2020

Effect of YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT 2A receptor antagonistic activity, on a marble-burying behavior test as an obsessive-compulsive disorder model

1 reference

12 December 2020

Substance P is involved in the sensitization of the acoustic startle response by footshocks in rats

1 reference

12 December 2020

The psychopharmacology of tachykinin NK-3 receptors in laboratory animals

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12 December 2020

Amino-acid sequence of substance P.

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12 December 2020

Selective blockade of neurokinin-2 receptors produces antidepressant-like effects associated with reduced corticotropin-releasing factor function

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12 December 2020

Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

1 reference

12 December 2020

Responsiveness of mesolimbic, mesocortical, septal and hippocampal cholecystokinin and substance P neuronal systems to stress, in the male rat

1 reference

12 December 2020

Involvement of tachykinin NK1 receptor in the behavioral and immunological responses to swimming stress in mice

1 reference

12 December 2020

Serotonin modulates the levels of mRNAS coding for thyrotropin-releasing hormone and preprotachykinin by different mechanisms in medullary raphe neurons

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12 December 2020

Substance P induces a cardiovascular defense reaction in the rat: pharmacological characterization

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12 December 2020

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12 December 2020

Intra-amygdala injection of the substance P [NK(1) receptor] antagonist L-760735 inhibits neonatal vocalisations in guinea-pigs

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12 December 2020

Neurokinin-1 receptors are decreased in major depressive disorder

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12 December 2020

Demonstration of the efficacy and safety of a novel substance P (NK1) receptor antagonist in major depression

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12 December 2020

Short‐term restraint stress and s.c. saline injection alter the tissue levels of substance P and cholecystokinin in the peri‐aqueductal grey and limbic regions of rat brain

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12 December 2020

An unidentified depressor substance in certain tissue extracts

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12 December 2020

Noxious Cutaneous Thermal Stimuli Induce a Graded Release of Endogenous Substance P in the Spinal Cord: Imaging Peptide ActionIn Vivo

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12 December 2020

Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.

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12 December 2020

Neuropeptide converting and processing enzymes in the spinal cord and cerebrospinal fluid

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12 December 2020

Substance P serum levels are increased in major depression: preliminary results

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12 December 2020

Anxiolytic-like action of neurokinin substance P administered systemically or into the nucleus basalis magnocellularis region

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12 December 2020

Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions

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12 December 2020

Increased neurogenesis and brain‐derived neurotrophic factor in neurokinin‐1 receptor gene knockout mice

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12 December 2020

Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse

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12 December 2020

Positively reinforcing effects of the neurokinin substance P in the basal forebrain: mediation by its C-terminal sequence

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12 December 2020

The effects of tachykinins on inflammatory and immune cells

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12 December 2020

Noradrenergic neurons expressing substance P receptor (NK1) in the locus coeruleus complex: a double immunofluorescence study in the rat

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12 December 2020

Distinct mechanism for antidepressant activity by blockade of central substance P receptors

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12 December 2020

Substance P and neurodegenerative disorders. A speculative review

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12 December 2020

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

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12 December 2020

Stimulation of connective tissue cell growth by substance P and substance K.

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12 December 2020

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor

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12 December 2020

Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils.

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12 December 2020

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

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12 December 2020

Neurobiology of substance P and the NK1 receptor.

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12 December 2020

Wind-up of spinal cord neurones and pain sensation: much ado about something?

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12 December 2020

Regional distribution of substance P binding sites in the brainstem of the human newborn

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12 December 2020

The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation

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12 December 2020

Dynorphin A and substance P in the cerebrospinal fluid of schizophrenic patients

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12 December 2020

Effects of intravenous infusion of substance P on arginine vasopressin and oxytocin secretion in normal men.

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12 December 2020

The role of lateral septal NK1 receptors in mediating anxiogenic effects induced by intracerebroventricular injection of substance P.

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12 December 2020

CSF substance P immunoreactivity in affective disorders

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12 December 2020

Effect of neurokinin-I receptor antagonists on the function of 5-HT and noradrenaline neurons

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12 December 2020

Involvement of the D-2 dopamine receptor in the neuroleptic-induced decrease in nigral substance P

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12 December 2020

PSYCHOPHARMACOLOGY:Can the Placebo Be the Cure?

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12 December 2020

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function

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12 December 2020

NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats

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12 December 2020

Genetics and pathophysiology of affective disorders: relationship to fibromyalgia

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12 December 2020

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A

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12 December 2020

Differential response of substance P-containing subtypes of adrenomedullary cells to different stressors

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12 December 2020

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo

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12 December 2020

Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils

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12 December 2020

Studies in psychoneuroimmunology: psychological, immunological, and neuroendocrinological parameters in Israeli civilians during and after a period of Scud missile attacks.

1 reference

12 December 2020

Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils

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12 December 2020

The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles

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12 December 2020

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

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12 December 2020

Grooming behavior induced by substance P

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12 December 2020

Imaging substance P receptors (NK1) in the living human brain using positron emission tomography.

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12 December 2020

The role of peptides in treatment of psychiatric disorders.

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12 December 2020

Substance P: correlation of CSF and plasma levels

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12 December 2020

Acetylcholinesterase hydrolyzes substance P

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12 December 2020

Investigation of substance P transport across the blood-brain barrier

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12 December 2020

Neuropeptides--an overview.

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12 December 2020

Effects of the neuropeptide substance P on sleep, mood, and neuroendocrine measures in healthy young men.

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12 December 2020

Functional neurokinin 1 receptors for substance P are expressed by human vascular endothelium

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12 December 2020

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

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12 December 2020

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord

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12 December 2020

Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission

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12 December 2020

Search for a physiological role of substance P in gastrointestinal motility

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12 December 2020

Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene.

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12 December 2020

Beta-endorphin, but not substance-P, is increased by acute stress in humans

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12 December 2020

Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia

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12 December 2020

Modulation of cortical acetylcholine release by serotonin: the role of substance P interneurons

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12 December 2020

Elucidating the antidepressant actions of substance P (NK1 receptor) antagonists.

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12 December 2020

Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice

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12 December 2020

Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.

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12 December 2020

Anxiogenic-like effect induced by substance P injected into the lateral septal nucleus

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12 December 2020

Receptors and antagonists for substance P and related peptides

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12 December 2020

Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.

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12 December 2020

5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization.

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12 December 2020

Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869.

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12 December 2020

Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats

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12 December 2020

Validity of clinical trials of antidepressants

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12 December 2020

Reinforcing effects of neurokinin substance P in the ventral pallidum: mediation by the tachykinin NK1 receptor

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12 December 2020

Stereospecific blockade of marble-burying behaviour in mice by selective, non-peptidergic neurokinin1 (NK1) receptor antagonists

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12 December 2020

Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.

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12 December 2020

The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists

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12 December 2020

Tachykinin NK(3)receptor involvement in anxiety.

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12 December 2020

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.

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12 December 2020

Phylogeny of tachykinin receptor localization in the vertebrate central nervous system: apparent absence of neurokinin-2 and neurokinin-3 binding sites in the human brain

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12 December 2020

Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus.

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12 December 2020

Hippocampal volume reduction in major depression

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12 December 2020

Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

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12 December 2020

Substance P and Substance P Receptor Antagonists in the Pathogenesis and Treatment of Affective Disorders

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12 December 2020

The substance P antagonist L-760,735 inhibits stress-induced NK(1) receptor internalisation in the basolateral amygdala

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12 December 2020

Elevation of substance P-like peptides in the CSF of psychiatric patients

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12 December 2020

Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

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12 December 2020

Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).

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12 December 2020

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

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12 December 2020

The substance P (NK1) receptor antagonist (±)-CP-96,345 causes sedation and motor impairment in Swiss albino mice in the black-and-white box behavioral paradigm

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12 December 2020

Stress-induced changes in cholecystokinin and substance P concentrations in discrete regions of the rat hypothalamus

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12 December 2020

Structure and gene organization of bovine neuromedin K precursor

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12 December 2020

Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain

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12 December 2020

Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat.

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12 December 2020

Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication

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12 December 2020

Effect of substance P on basal and thyrotropin-releasing hormone-stimulated thyrotropin release in humans

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12 December 2020

Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis

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12 December 2020

Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse.

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12 December 2020

A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

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12 December 2020

Modulation of brain stem monoamines and gamma-aminobutyric acid by NK1 receptors in rats

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12 December 2020

Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat.

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12 December 2020

Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

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12 December 2020

Serum levels of substance P and response to antidepressant pharmacotherapy

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12 December 2020

The substance P (NK1) receptor antagonist L-760735 inhibits fear conditioning in gerbils

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12 December 2020

Luteinizing hormone response to an intravenous infusion of substance P in normal men

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12 December 2020

Clinical experience with substance P receptor (NK1) antagonists in depression.

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12 December 2020

Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test.

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12 December 2020

Comparative behavioural profile of centrally administered tachykinin NK1, NK2 and NK3 receptor agonists in the guinea-pig

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12 December 2020

Detection of N-terminally extended substance P but not of substance P in human cerebrospinal fluid: quantitation with HPLC-radioimmunoassay

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12 December 2020

Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils

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12 December 2020

The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats

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12 December 2020

Effects of substance P and selected other neuropeptides on the synthesis of interleukin-1 beta and interleukin-6 in human monocytes: a re-examination

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12 December 2020

The chronic psychosocial stress paradigm in male tree shrews: evaluation of a novel animal model for depressive disorders

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12 December 2020

Serotonin and substance P co-exist in dorsal raphe neurons of the human brain

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12 December 2020

Effect of immobilization stress on neuropeptides and their receptors in rat central nervous system

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12 December 2020

Effects of sequential removal of rats from a group cage, and of individual housing of rats, on substance P, cholecystokinin and somatostatin levels in the periaqueductal grey and limbic regions

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12 December 2020

The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells

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12 December 2020

Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.

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12 December 2020

Identification, localization and receptor characterization of novel mammalian substance P-like peptides

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12 December 2020

Central injection of substance P elicits grooming behavior and motor inhibition in mice

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12 December 2020

Inhibition of shock-induced foot tapping behaviour in the gerbil by a tachykinin NK1 receptor antagonist

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12 December 2020

Effects of acute systemic treatment with the 5 HT-uptake blocker alaproclate on tissue levels and release of substance P in rat periaqueductal grey

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12 December 2020

Substance P in the human brain

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12 December 2020

Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline

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12 December 2020

Localization of neurons expressing substance P and neurokinin B gene transcripts in the human hypothalamus and basal forebrain

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12 December 2020

Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatment

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12 December 2020

Electron microscopic localization of substance P and enkephalin in axon terminals related to dendrites of catecholaminergic neurons

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12 December 2020

Trophic effect of various neuropeptides on the cultured ventral spinal cord of rat embryo

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12 December 2020

The promise of substance P inhibitors in fibromyalgia

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12 December 2020

Conditioned place aversion produced by microinjections of substance P into the periaqueductal gray of rats

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12 December 2020

Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion

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12 December 2020

Rewarding effects of opiates are absent in mice lacking the receptor for substance P.

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12 December 2020

Serotonin regulation of neostriatal tachykinins following neonatal 6-hydroxydopamine lesions

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12 December 2020

Distribution of substance P-like immunoreactive structures in the brainstem of the adult human brain: an immunocytochemical study

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12 December 2020

Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes

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12 December 2020

Coexistence of peptides with classical neurotransmitters

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12 December 2020

Endogenous substance P inhibits the expression of corticotropin-releasing hormone during a chronic inflammatory stress.

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12 December 2020

Identification and cDNA sequence of delta-preprotachykinin, a fourth splicing variant of the rat substance P precursor

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12 December 2020

Effects of whole-body vibration stress on substance P- and neurotensin-like immunoreactivity in the rat brain

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12 December 2020

Activation by stress of the habenulo-interpeduncular substance P neurons in the rat

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12 December 2020

Intravenously infused substance P enhances basal and growth hormone (GH) releasing hormone-stimulated GH secretion in normal men

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12 December 2020

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice.

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12 December 2020

Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid.

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12 December 2020

Antagonists at the neurokinin receptors--recent patent literature.

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12 December 2020

Evidence that substance P is utilized in medial amygdaloid facilitation of defensive rage behavior in the cat.

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12 December 2020

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume.

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12 December 2020

Ca(2 )-dependent exocytosis in the somata of dorsal root ganglion neurons

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12 December 2020

10.2165/00023210-200519040-00001

Identifiers

DOI

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Dimensions Publication ID

2 August 2017

1009799648

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