MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia (Q34386922)

1 August 2017

title

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia (English)

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1 August 2017

0 references

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Christopher R Vakoc

9

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Ross A. Dickins

Ross A Dickins

8

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Nikolaus Schultz

Nikolaus Schultz

5

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Johannes Zuber

Johannes Zuber

15

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Michelle M Le Beau

12

Michelle M LeBeau

1 reference

1 August 2017

Chong Chen

1

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1 August 2017

Yu Liu

2

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1 August 2017

Amy R Rappaport

3

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1 August 2017

Thomas Kitzing

4

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1 August 2017

Zhen Zhao

6

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1 August 2017

Aditya S Shroff

7

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1 August 2017

James E Bradner

10

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1 August 2017

Wendy Stock

11

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1 August 2017

Kevin M Shannon

13

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1 August 2017

Scott Kogan

14

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1 August 2017

Scott W Lowe

16

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1 August 2017

publication date

1 May 2014

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1 August 2017

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1 August 2017

volume

25

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1 August 2017

issue

5

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1 August 2017

page(s)

652-665

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Discovery and saturation analysis of cancer genes across 21 tumour types

1 August 2017

cites work

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H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

6 July 2018

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Mutational landscape and significance across 12 major cancer types

6 July 2018

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

6 July 2018

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RNA-guided human genome engineering via Cas9

6 July 2018

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Multiplex genome engineering using CRISPR/Cas systems

6 July 2018

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CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

6 July 2018

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Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

6 July 2018

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A tumour suppressor network relying on the polyamine-hypusine axis

6 July 2018

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6 July 2018

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A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

6 July 2018

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Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

6 July 2018

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Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.

6 July 2018

1 reference

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Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

6 July 2018

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

6 July 2018

1 reference

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

6 July 2018

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Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

6 July 2018

1 reference

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

6 July 2018

1 reference

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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

6 July 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

6 July 2018

1 reference

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Analysis of the coding genome of diffuse large B-cell lymphoma

6 July 2018

1 reference

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Chromosomal minimal critical regions in therapy-related leukemia appear different from those of de novo leukemia by high-resolution aCGH.

6 July 2018

1 reference

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The genetic landscape of the childhood cancer medulloblastoma

6 July 2018

1 reference

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p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Identification of a common microdeletion cluster in 7q21.3 subband among patients with myeloid leukemia and myelodysplastic syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Mouse models of human AML accurately predict chemotherapy response

6 July 2018

1 reference

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Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

6 July 2018

1 reference

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Molecular genetic pathways as therapeutic targets in acute myeloid leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

MLL5 contributes to hematopoietic stem cell fitness and homeostasis

6 July 2018

1 reference

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Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Comparative lesion sequencing provides insights into tumor evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Myelodysplastic syndromes: the complexity of stem-cell diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Novel patterns of genome rearrangement and their association with survival in breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Second-generation shRNA libraries covering the mouse and human genomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

A stem cell molecular signature

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Genetics of myeloid leukemias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Tumor spectrum analysis in p53-mutant mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Disclosure of Candidate Genes in Acute Myeloid Leukemia With Complex Karyotypes Using Microarray-Based Molecular Characterization

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206212

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

9 December 2018

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12 December 2020

Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis

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12 December 2020

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

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12 December 2020

Exome sequencing of liver fluke-associated cholangiocarcinoma

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12 December 2020

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

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12 December 2020

10.1016/J.CCR.2014.03.016

Identifiers

DOI

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1 August 2017

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1 August 2017

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