Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. (Q34385690)

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English	Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.	scientific article

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15 February 2020

Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117 (English)

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15 February 2020

protein ubiquitination

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based on heuristic

inferred from title

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15 February 2020

Kenneth M. Scaglione

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15 February 2020

Kojo Elenitoba-Johnson

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15 February 2020

Annalisa Pastore

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Annalisa Pastore

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15 February 2020

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Jessica R Blount

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15 February 2020

Venkatesha Basrur

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15 February 2020

Kevin P Conlon

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15 February 2020

Henry L Paulson

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13 October 2010

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15 February 2020

Journal of Biological Chemistry

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15 February 2020

285

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15 February 2020

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15 February 2020

39303-39313

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15 February 2020

Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.

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6 July 2018

Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels

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6 July 2018

Proteotoxic stress increases nuclear localization of ataxin-3

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6 July 2018

Breaking the chains: structure and function of the deubiquitinases

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6 July 2018

Defining the human deubiquitinating enzyme interaction landscape

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6 July 2018

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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6 July 2018

The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.

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6 July 2018

Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

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6 July 2018

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

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6 July 2018

To ubiquitinate or to deubiquitinate: it all depends on the partners

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6 July 2018

Protein partners of deubiquitinating enzymes

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6 July 2018

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.

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6 July 2018

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25

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6 July 2018

Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination

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6 July 2018

Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity

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6 July 2018

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization

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6 July 2018

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

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6 July 2018

UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself

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6 July 2018

A genomic and functional inventory of deubiquitinating enzymes

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6 July 2018

Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6

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6 July 2018

Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3.

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6 July 2018

The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition

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6 July 2018

Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

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6 July 2018

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation

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6 July 2018

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

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6 July 2018

Mechanism and function of deubiquitinating enzymes

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6 July 2018

Human disorders of ubiquitination and proteasomal degradation

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6 July 2018

Crystal structure of human otubain 2.

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6 July 2018

Molecular clearance of ataxin-3 is regulated by a mammalian E4

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6 July 2018

Deubiquitinating enzymes: their roles in development, differentiation, and disease

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6 July 2018

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6 July 2018

Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

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6 July 2018

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

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6 July 2018

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

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6 July 2018

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

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6 July 2018

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

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6 July 2018

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search

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6 July 2018

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

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6 July 2018

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

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6 July 2018

Structural basis for the specificity of ubiquitin C-terminal hydrolases

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6 July 2018

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 Å resolution

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6 July 2018

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

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6 July 2018

Characterisation of the unstable expanded CAG repeat in the MJD1 gene in four Brazilian families of Portuguese descent with Machado-Joseph disease

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6 July 2018

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

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6 July 2018

Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.

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21 January 2018

Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites

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21 January 2018

Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions

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21 January 2018

Recruitment of nonexpanded polyglutamine proteins to intranuclear aggregates in neuronal intranuclear hyaline inclusion disease

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21 January 2018

Linkage disequilibrium at the Machado-Joseph disease/spinal cerebellar ataxia 3 locus: evidence for a common founder effect in French and Portuguese-Brazilian families as well as a second ancestral Portuguese-Azorean mutation.

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27 October 2018

Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1

1 reference

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12 December 2020

based on heuristic

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Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.181610

1 reference

Europe PubMed Central

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15 February 2020

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15 February 2020

PubMed publication ID

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15 February 2020

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