A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy. (Q34373138)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24906121 AND SRC:MED&resulttype=core&format=json

20 March 2020

title

A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24906121 AND SRC:MED&resulttype=core&format=json

20 March 2020

0 references

Philip L Lorenzi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24906121 AND SRC:MED&resulttype=core&format=json

20 March 2020

John N Weinstein

series ordinal

4

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20 March 2020

publication date

12 May 2014

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20 March 2020

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20 March 2020

volume

10

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20 March 2020

issue

7

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20 March 2020

page(s)

1316-1326

1 reference

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Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors

20 March 2020

cites work

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L-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia

6 July 2018

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Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition

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NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

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6 July 2018

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The diverse and complex roles of NF-κB subunits in cancer

6 July 2018

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

6 July 2018

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Microautophagy in mammalian cells: revisiting a 40-year-old conundrum

6 July 2018

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A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.

6 July 2018

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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

6 July 2018

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RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

6 July 2018

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A differential autophagic response to hyperglycemia in the developing murine embryo

6 July 2018

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Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma.

6 July 2018

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Principles and current strategies for targeting autophagy for cancer treatment

6 July 2018

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

6 July 2018

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Chaperone-mediated autophagy at a glance

6 July 2018

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Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

6 July 2018

1 reference

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Autophagy modulation for cancer therapy

6 July 2018

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Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway

6 July 2018

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The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research

6 July 2018

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HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

6 July 2018

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The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase

6 July 2018

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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

6 July 2018

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The RB-E2F1 pathway regulates autophagy.

6 July 2018

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A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions

6 July 2018

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Network organization of the human autophagy system

6 July 2018

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Regulation of autophagy by ATF4 in response to severe hypoxia.

6 July 2018

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The molecular mechanism of mitochondria autophagy in yeast

6 July 2018

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Ammonia derived from glutaminolysis is a diffusible regulator of autophagy

6 July 2018

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Targeting metabolic transformation for cancer therapy.

6 July 2018

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Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

6 July 2018

1 reference

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Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.

6 July 2018

1 reference

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Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

6 July 2018

1 reference

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Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

6 July 2018

1 reference

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The double-edged sword of autophagy modulation in cancer

6 July 2018

1 reference

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The autophagy effector Beclin 1: a novel BH3-only protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Stimulation of autophagy by the p53 target gene Sestrin2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells

6 July 2018

1 reference

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Bidirectional transport of amino acids regulates mTOR and autophagy

6 July 2018

1 reference

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Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase

6 July 2018

1 reference

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Regulation of TORC1 by Rag GTPases in nutrient response

6 July 2018

1 reference

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Regulation of autophagy by cytoplasmic p53

6 July 2018

1 reference

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Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum

6 July 2018

1 reference

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

6 July 2018

1 reference

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VennMaster: area-proportional Euler diagrams for functional GO analysis of microarrays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

6 July 2018

1 reference

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Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

6 July 2018

1 reference

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siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

6 July 2018

1 reference

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Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling.

6 July 2018

1 reference

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Autophagy delays apoptotic death in breast cancer cells following DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Wnt-5a/Ca2 -induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Generalized Venn diagrams: a new method of visualizing complex genetic set relations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Analyses of Galpha-interacting protein and activator of G-protein-signaling-3 functions in macroautophagy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Uth1p is involved in the autophagic degradation of mitochondria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

The recombinant alpha isoform of protein kinase CK1 from Xenopus laevis can phosphorylate tyrosine in synthetic substrates.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203555

6 July 2018

Functions of lysosomes

1 reference

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Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276.

6 July 2018

1 reference

The WT1 Wilms' tumor suppressor gene is a downstream target for insulin-like growth factor-I (IGF-I) action in PC12 cells.

21 January 2018

1 reference

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

21 January 2018

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Role of AMP-activated protein kinase in autophagy and proteasome function

21 January 2018

1 reference

Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose.

21 January 2018

1 reference

Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.

21 January 2018

1 reference

Glutaminolysis activates Rag-mTORC1 signaling.

21 January 2018

1 reference

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

21 January 2018

1 reference

Inositol hexaphosphate-loaded red blood cells prevent in vitro sickling.

21 January 2018

1 reference

Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase

21 January 2018

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12 December 2020

Purification and characterization of casein kinase II from lactating rabbit mammary gland

1 reference

12 December 2020

High glucose stimulates GRO secretion from rat microglia via ROS, PKC, and NF-kappaB pathways

1 reference

12 December 2020

Selective uptake of cytosolic, peroxisomal, and plasma membrane proteins into the yeast lysosome for degradation

1 reference

12 December 2020

In vitro phosphorylation of the movement protein of tomato mosaic tobamovirus by a cellular kinase

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12 December 2020

Identifiers

DOI

10.4161/AUTO.28773

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24906121 AND SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24906121 AND SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

24906121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24906121 AND SRC:MED&resulttype=core&format=json