Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes (Q34367675)

1 August 2017

title

Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes (English)

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1 August 2017

Heather Hajovsky

1

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1 August 2017

Gang Hu

2

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1 August 2017

Yakov Koen

3

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1 August 2017

Diganta Sarma

4

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1 August 2017

Wenqi Cui

5

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1 August 2017

David S Moore

6

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1 August 2017

Jeff L Staudinger

7

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1 August 2017

Robert P Hanzlik

8

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1 August 2017

publication date

17 August 2012

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Chemical Research in Toxicology

1 August 2017

published in

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1 August 2017

volume

25

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1 August 2017

issue

9

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1 August 2017

page(s)

1955-1963

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Synthesis of carbon-14, carbon-13 and deuterium labeled forms of thioacetamide and thioacetamide S-oxide

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites

6 July 2018

1 reference

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Studies on the Metabolism and Biological Activity of the Epimers of Sulindac

6 July 2018

1 reference

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Expression analysis of early response-related genes in rat liver epithelial cells exposed to thioacetamide in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Potentiation of thioacetamide-induced hepatotoxicity in alloxan- and streptozotocin-diabetic rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Inhibitory effect of fumaric acid on hepatocarcinogenesis by thioacetamide in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system

6 July 2018

1 reference

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Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Saturation toxicokinetics of thioacetamide: role in initiation of liver injury

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice

27 October 2018

1 reference

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Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma

27 October 2018

1 reference

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Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality

27 October 2018

1 reference

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Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Potentiation of thioacetamide hepatotoxicity by phenobarbital pretreatment in rats. Inducibility of FAD monooxygenase system and age effect

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Response of isolated hepatocytes to organic and inorganic cytotoxins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444651

Liver Tumors in Rats Fed Thiourea or Thioacetamide

27 October 2018

1 reference

12 December 2020

Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital

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12 December 2020

Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide

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12 December 2020

Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide

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12 December 2020

The metabolism of ethionamide and its sulphoxide

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12 December 2020

Studies of the mechanism of metabolism of thioacetamide s-oxide by rat liver microsomes

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12 December 2020

The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers

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12 December 2020

Renal metabolism of sulindac: functional implications

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12 December 2020

Dietary indole-3-carbinol inhibits FMO activity and the expression of flavin-containing monooxygenase form 1 in rat liver and intestine

1 reference

12 December 2020

Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide

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12 December 2020

Preparation of hepatocytes

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12 December 2020

Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices

1 reference

12 December 2020

Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes

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12 December 2020

Identifiers

DOI

10.1021/TX3002719

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1 August 2017

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1 August 2017

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