Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis (Q34361034)

1 August 2017

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title

Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis (English)

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glycogen metabolic process

1 August 2017

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Radziuk J

1

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1 August 2017

Pye S

series ordinal

2

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1 August 2017

publication date

1 July 2001

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Diabetes - Metabolism: Research and Reviews

1 August 2017

published in

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1 August 2017

volume

17

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1 August 2017

issue

4

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1 August 2017

page(s)

250-272

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Muscle Amino Acid Metabolism and Gluconeogenesis

1 August 2017

cites work

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Glycogen synthesis in the perfused liver of the starved rat.

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Restoration of glycogenesis in hepatocytes from starved rats

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Glycogen synthesis by rat hepatocytes

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Hormone-fuel interrelationships during fasting

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Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting

21 January 2018

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Influence of Endogenous Insulin Secretion on Splanchnic Glucose and Amino Acid Metabolism in Man

21 January 2018

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Effects of lactate on pathways of glycogen formation in the perfused rat liver

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The metabolic clearance of glucose: measurement and meaning

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A non-invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man.

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Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR.

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Glycogen turnover during refeeding in the postabsorptive dog: implications for the estimation of glycogen formation using tracer methods

21 January 2018

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Glycoconjugates as noninvasive probes of intrahepatic metabolism: pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation

21 January 2018

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Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state

21 January 2018

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Applications of mass isotopomer analysis to nutrition research

21 January 2018

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Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

21 January 2018

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Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

21 January 2018

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Effect of differences in glucose tolerance on insulin's ability to regulate carbohydrate and free fatty acid metabolism in obese individuals

21 January 2018

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Defective blood glucose counter-regulation in diabetics is a selective form of autonomic neuropathy

21 January 2018

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Acarbose: a review of US clinical experience

21 January 2018

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The effect of systemic venous drainage of the pancreas on insulin sensitivity in dogs

21 January 2018

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Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type I diabetic recipients

21 January 2018

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Pathogenesis of NIDDM. A balanced overview

21 January 2018

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Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load

21 January 2018

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Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus.

21 January 2018

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Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans.

21 January 2018

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Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin

21 January 2018

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The physiological significance of the secretion of endogenous insulin into the portal circulation. IV. Hepatic uptake of glucose during glucose infusion in non-diabetic dogs

21 January 2018

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Influence of Oral Glucose Ingestion on Splanchnic Glucose and Gluconeogenic Substrate Metabolism in Man

21 January 2018

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Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange

21 January 2018

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Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism

21 January 2018

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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

21 January 2018

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Initial splanchnic extraction of ingested glucose in normal man.

21 January 2018

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Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy

21 January 2018

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Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues

21 January 2018

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Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM.

21 January 2018

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Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs

21 January 2018

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Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog

21 January 2018

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Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs

21 January 2018

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The role of the liver in the disposal of orally administered 14C-glucose in the normal rat

21 January 2018

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Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

21 January 2018

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Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

21 January 2018

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

21 January 2018

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Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations

21 January 2018

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Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects

21 January 2018

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

21 January 2018

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Competitive inhibition of liver glucokinase by its regulatory protein

21 January 2018

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Metabolic regulation of gene transcription in mammals

21 January 2018

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Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate

21 January 2018

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Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia

21 January 2018

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New knowledge regarding glucose-6 phosphatase gene and protein and their roles in the regulation of glucose metabolism

21 January 2018

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Glucose-6-Phosphatase Structure, Regulation, and Function: An Update

21 January 2018

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A re-evaluation of GLUT 7.

21 January 2018

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Metabolic intermediates as potential regulators of glucose-6-phosphatase

21 January 2018

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Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: gene structure and 5'-flanking sequence

21 January 2018

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Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes

21 January 2018

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Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats

21 January 2018

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The discovery of glycogenin and the priming mechanism for glycogen biogenesis

21 January 2018

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Specific features of glycogen metabolism in the liver

21 January 2018

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Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis

21 January 2018

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Glucose induces the translocation of glycogen synthase to the cell cortex in rat hepatocytes

21 January 2018

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The Stimulation of Glycogen Synthesis and of Glycogen Synthetase in the Liver by the Administration of Glucose

21 January 2018

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The Control of Glycogen Metabolism in the Liver

21 January 2018

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Regulation of glycogen synthesis in the liver.

21 January 2018

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The inactivation of glycogen phosphorylase is not a prerequisite for the activation of liver glycogen synthase

21 January 2018

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Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes

21 January 2018

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Simultaneous synthesis and degradation of rat liver glycogen. An in vivo nuclear magnetic resonance spectroscopic study

21 January 2018

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Translocation and aggregation of hepatic glycogen synthase during the fasted-to-refed transition in rats

21 January 2018

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Demonstration of a glycogen/glucose 1-phosphate cycle in hepatocytes from fasted rats. Selective inactivation of phosphorylase by 2-deoxy-2-fluoro-alpha-D-glucopyranosyl fluoride

21 January 2018

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Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans

21 January 2018

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Loss of the hepatic glycogen-binding subunit (GL) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats.

21 January 2018

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Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms

21 January 2018

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Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI.

21 January 2018

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Variability of biochemical and clinical phenotype in X-linked liver glycogenosis with mutations in the phosphorylase kinase PHKA2 gene

21 January 2018

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Role of the direct and indirect pathways for glycogen synthesis in rat liver in the postprandial state

21 January 2018

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Quantitation of the pathways of hepatic glycogen formation on ingesting a glucose load

21 January 2018

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Determination of pathways of glycogen synthesis and the dilution of the three-carbon pool with [U-13C]glucose

21 January 2018

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Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy

21 January 2018

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Determination of the glycogen synthesis pathway by 13C nuclear magnetic resonance analysis

21 January 2018

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Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats

21 January 2018

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Gut exchange of glucose and lactate in basal state and after oral glucose ingestion in postoperative patients

21 January 2018

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Sources of carbon for hepatic glycogen synthesis in the conscious dog

21 January 2018

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The contribution of pyruvate cycling to loss of [6-3H]glucose during conversion of glucose to glycogen in hepatocytes: effects of insulin, glucose and acinar origin of hepatocytes

21 January 2018

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Glycogen synthesis in amphibian oocytes: evidence for an indirect pathway

21 January 2018

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Lactate Release from Isolated Rat Adipocytes: Influence of Cell Size, Glucose Concentration, Insulin and Epinephrine

21 January 2018

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Evidence for lactate production by human adipose tissue in vivo

21 January 2018

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Energy metabolism and the skin

21 January 2018

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Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects

21 January 2018

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Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

21 January 2018

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Glycogen synthesis from pyruvate in the periportal and from glucose in the perivenous zone in perfused livers from fasted rats

21 January 2018

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Role of liver in pathophysiology of NIDDM

21 January 2018

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Peripheral tissue glucose uptake is not reduced after an oral glucose load in Southern Italian subjects at risk of developing non-insulin-dependent diabetes mellitus

21 January 2018

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Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM.

21 January 2018

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Evidence of increased systemic glucose production and gluconeogenesis in an early stage of NIDDM.

21 January 2018

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Insulin sensitivity accounts for glucose and lactate kinetics after intravenous glucose injection

21 January 2018

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Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin

21 January 2018

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Lactate Production from Glucose and Response to Insulin in Perifused Adipocytes from Mesenteric and Epididymal Regions of Lean and Obese Rats

21 January 2018

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Hepatic Metabolism of Glucose and Glycogen in Fed Rats

21 January 2018

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7 January 2021

Liver Glycogen in Man –- the Effect of Total Starvation or a Carbohydrate-Poor Diet Followed by Carbohydrate Refeeding

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7 January 2021

Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects

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7 January 2021

The Effects of an Alpha-Glucoside Hydrolase Inhibitor on Glycemia and the Absorption of Sucrose in Man Determined Using a Tracer Method

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7 January 2021

Tracer methods and the metabolic disposal of a carbohydrate load in man

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7 January 2021

Influences of glucose loading and of injected insulin on hepatic glucose output

1 reference

7 January 2021

Insulin action in non-insulin-dependent diabetes mellitus: the relationship between hepatic and extrahepatic insulin resistance and obesity

1 reference

7 January 2021

Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog

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7 January 2021

Influence of Maturity-onset Diabetes on Splanchnic Glucose Balance After Oral Glucose Ingestion

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7 January 2021

Oral glucose tolerance test: effect of different glucose loads on splanchnic carbohydrate and substrate metabolism in healthy man

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7 January 2021

Postprandial substrate deposition in human forearm and adipose tissues in vivo

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7 January 2021

Forearm Glucose Uptake During the Oral Glucose Tolerance Test in Normal Subjects

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7 January 2021

The analysis of glucose measurements by computer simulation

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7 January 2021

Glucose uptake and production during the oral glucose tolerance test

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7 January 2021

Hepatic glycogen formation by direct uptake of glucose following oral glucose loading in man

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7 January 2021

The disposal of an oral glucose load in healthy subjects. A quantitative study

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7 January 2021

The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man

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7 January 2021

A portal-arterial glucose concentration gradient as a signal for an insulin-dependent net glucose uptake in perfused rat liver

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7 January 2021

Sensing by intrahepatic muscarinic nerves of a portal-arterial glucose concentration gradient as a signal for insulin-dependent glucose uptake in the perfused rat liver

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7 January 2021

Both positive and negative portal venous and hepatic arterial glucose gradients stimulate hepatic glucose uptake after the same amount of glucose is infused into the splanchnic bed in conscious dogs

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7 January 2021

Liver and muscle glycogen in man after glucose and fructose infusion

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7 January 2021

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype

1 reference

7 January 2021

Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus

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7 January 2021

Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis

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7 January 2021

Differential Metabolic Effects of Adenovirus-mediated Glucokinase and Hexokinase I Overexpression in Rat Primary Hepatocytes

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7 January 2021

Glucose 6-Phosphate Produced by Glucokinase, but Not Hexokinase I, Promotes the Activation of Hepatic Glycogen Synthase

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7 January 2021

Glucose transport and glucose 6-phosphate hydrolysis in intact rat liver microsomes

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7 January 2021

Evidence for suppression of hepatic glucose-6-phosphatase with carbohydrate feeding

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7 January 2021

Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase

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7 January 2021

Carbon Flux via the Pentose Phosphate Pathway Regulates the Hepatic Expression of the Glucose-6-phosphatase and Phosphoenolpyruvate Carboxykinase Genes in Conscious Rats

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7 January 2021

The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose

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7 January 2021

Liver glycogen metabolism: an overview

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7 January 2021

Stimulation of liver glycogen particle synthase D phosphatase activity by caffeine, AMP, and glucose 6-phosphate

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7 January 2021

In vivo regulation of liver and skeletal muscle glycogen synthase activity by glucose and insulin

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7 January 2021

Insulin and glucose suppress hepatic glycogenolysis by distinct enzymatic mechanisms

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7 January 2021

Inhibition of phosphorylase-a by fructose-1-phosphate, alpha-glycerophosphate and fructose-1,6-diphosphate: explanation for fructose-induced hypoglycaemia in hereditary fructose intolerance and fructose-1,6-diphosphatase deficiency

1 reference

7 January 2021

Correction factor for the estimation of plasma glucose synthesis from the transfer of 14C-atoms from labelled substrate in vivo: A preliminary report

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7 January 2021

Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state

1 reference

7 January 2021

The effects of ingested and intravenous glucose on forearm uptake of glucose and glucogenic substrate in normal man

1 reference

7 January 2021

The utilization of glucose and production of lactate by in vitro preparations of rat small intestine: effects of vascular perfusion

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7 January 2021

In vitro study on the contribution of the rat intestine-pancreas to glucose homeostasis

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7 January 2021

The Role of the Skin in Carbohydrate Metabolism

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7 January 2021

Effects of Metformin on Lactate Uptake and Gluconeogenesis in the Perfused Rat Liver

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7 January 2021

Lactate and pyruvate stimulate the conversion of glucose to glycogen in hepatocytes by a mechanism that does not involve gluconeogenic flux

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7 January 2021

Inhibition of glucose-6-phosphate phosphohydrolase by 3-mercaptopicolinate and two analogs is metabolically directive

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7 January 2021

Effects of 3-mercaptopicolinic acid and a derivative of chlorogenic acid (S-3483) on hepatic and islet glucose-6-phosphatase activity

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7 January 2021

The role of cell swelling in the stimulation of glycogen synthesis by insulin

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7 January 2021

Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver

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7 January 2021

Autoregulatory shift from fructolysis to lactate gluconeogenisis in rat hepatocyte suspensions. The problem of metabolic zonation of liver parenchyma

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7 January 2021

Measurement of metabolic fluxes through pyruvate kinase, phosphoenolpyruvate carboxykinase, pyruvate dehydrogenase, and pyruvate carboxylate in hepatocytes of different acinar origin

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7 January 2021

Glutamine and alanine metabolism in NIDDM

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7 January 2021

Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients

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7 January 2021

Hepatic glycogen and lactate handling in dietary obese rats

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7 January 2021

Identifiers

DOI

10.1002/DMRR.217

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1 August 2017

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