Elevated microRNA-34a in obesity reduces NAD levels and SIRT1 activity by directly targeting NAMPT. (Q34356019)

1 August 2017

title

Elevated microRNA-34a in obesity reduces NAD levels and SIRT1 activity by directly targeting NAMPT. (English)

1 reference

1 August 2017

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Xiaoling Li

8

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author name string

Sung-E Choi

1

1 reference

1 August 2017

Ting Fu

2

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1 August 2017

Sunmi Seok

3

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1 August 2017

Dong-Hyun Kim

4

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1 August 2017

Eunkyung Yu

5

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1 August 2017

Kwan-Woo Lee

6

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1 August 2017

Yup Kang

7

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1 August 2017

Byron Kemper

9

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1 August 2017

Jongsook Kim Kemper

10

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1 August 2017

publication date

11 August 2013

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1 August 2017

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1 August 2017

volume

12

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1 August 2017

issue

6

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1 August 2017

page(s)

1062-1072

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators

1 August 2017

cites work

1 reference

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Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition

6 July 2018

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6 July 2018

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6 July 2018

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FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states

6 July 2018

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6 July 2018

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Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

6 July 2018

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Circadian clock feedback cycle through NAMPT-mediated NAD biosynthesis

6 July 2018

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Circadian control of the NAD salvage pathway by CLOCK-SIRT1

6 July 2018

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Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes

6 July 2018

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AMPK regulates energy expenditure by modulating NAD metabolism and SIRT1 activity

6 July 2018

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SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

6 July 2018

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miR-34a repression of SIRT1 regulates apoptosis

6 July 2018

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6 July 2018

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Sirt1 protects against high-fat diet-induced metabolic damage

6 July 2018

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6 July 2018

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6 July 2018

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

6 July 2018

1 reference

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Resveratrol improves health and survival of mice on a high-calorie diet

6 July 2018

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

6 July 2018

1 reference

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Substrate-specific activation of sirtuins by resveratrol

6 July 2018

1 reference

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

6 July 2018

1 reference

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Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3838500

Small RNA regulators of gene expression.

27 October 2018

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Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23834033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/ACEL.12135

1 reference

1 August 2017

1 reference

1 August 2017

1 reference