Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors (Q34348449)

1 August 2017

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title

Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors (English)

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1 August 2017

author

Salvador Aznar Benitah

object named as

Aznar S

series ordinal

1

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author name string

Lacal JC

series ordinal

2

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1 August 2017

publication date

1 January 2001

1 reference

Progress in Molecular Biology and Translational Science

1 August 2017

published in

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1 August 2017

volume

67

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1 August 2017

page(s)

193-234

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Rho GTPases and signaling networks

1 August 2017

cites work

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A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

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Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling

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Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

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Cytokinesis: IQGAPs find a function

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Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin

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7 January 2021

From egg to epithelium

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7 January 2021

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

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7 January 2021

Cadherins in cancer: implications for invasion and metastasis

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7 January 2021

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

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7 January 2021

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

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7 January 2021

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

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7 January 2021

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

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7 January 2021

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

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7 January 2021

Rho proteins induce metastatic properties in vivo

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7 January 2021

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

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7 January 2021

Rho family proteins in cell adhesion and cell migration.

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7 January 2021

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

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7 January 2021

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

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7 January 2021

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

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7 January 2021

Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1.

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7 January 2021

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

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7 January 2021

Rho GTPases are over-expressed in human tumors.

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7 January 2021

The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation

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7 January 2021

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

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7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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7 January 2021

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

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7 January 2021

Identification of a mouse p21Cdc42/Rac activated kinase

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

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7 January 2021

Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

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7 January 2021

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

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7 January 2021

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

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7 January 2021

Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2 ) sensitivity of smooth muscle contraction

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7 January 2021

PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae

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7 January 2021

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

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7 January 2021

PAK3 mutation in nonsyndromic X-linked mental retardation

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7 January 2021

Mechanism of activation of Pak1 kinase by membrane localization

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7 January 2021

A novel regulator of p21-activated kinases

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion

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7 January 2021

Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1 reference

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7 January 2021

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

1 reference

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7 January 2021

The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

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7 January 2021

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

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7 January 2021

Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation

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7 January 2021

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

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7 January 2021

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

1 reference

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7 January 2021

Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity

1 reference

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7 January 2021

Regulation of urokinase receptor transcription by Ras- and Rho-family GTPases

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

1 reference

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7 January 2021

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 reference

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7 January 2021

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Transformation mediated by RhoA requires activity of ROCK kinases

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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7 January 2021

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of membrane-bound phospholipase D by protein kinase C in HL60 cells: synergistic action of a small GTP-binding protein RhoA.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Role of Rho family proteins in phospholipase D activation by growth factors

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of phospholipase D1 by Cdc42 requires the Rho insert region

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Role of rho proteins in agonist regulation of phospholipase D in HL-60 cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Interaction of the small G protein RhoA with the C terminus of human phospholipase D1

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Determination of interaction sites on the small G protein RhoA for phospholipase D

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Synergistic Activation of Rat Brain Phospholipase D by ADP-ribosylation Factor and rhoA p21, and Its Inhibition by Clostridium botulinum C3 Exoenzyme

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid‐dependent signaling

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

ADP-ribosylation factor proteins mediate agonist-induced activation of phospholipase D

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A role for rho-kinase in rho-controlled phospholipase D stimulation by the m3 muscarinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Role of phospholipase D in laminin-induced production of gelatinase A (MMP-2) in metastatic cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Release of gelatinase A (matrix metalloproteinase 2) induced by photolysis of caged phosphatidic acid in HT 1080 metastatic fibrosarcoma cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Modulation of the metastatic activity of melanoma cells by laminin and fibronectin

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Nuclear translocation of RhoA mediates the mitogen-induced activation of phospholipase D involved in nuclear envelope signal transduction

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The small GTP-binding protein Rho potentiates AP-1 transcription in T cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Identification of a novel nuclear factor-kappaB sequence involved in expression of urokinase-type plasminogen activator receptor

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Interaction of PKN with alpha-actinin

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PKN associates and phosphorylates the head-rod domain of neurofilament protein

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Stimulation of vgf gene expression by NGF is mediated through multiple signal transduction pathways involving protein phosphorylation

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The role of PKN in the regulation of alphaB-crystallin expression via heat shock transcription factor 1

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element

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https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Arachidonic acid, a principal product of Rac‐activated phospholipase A2, stimulates c‐fos serum response element via Rho‐dependent mechanism

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of PKN, a novel 120-kDa protein kinase with leucine zipper-like sequences, by unsaturated fatty acids and by limited proteolysis.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Mechanism of activation of a human oncogene

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Raf-1 activates MAP kinase-kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Regulation of transcription by MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between Ras -mutated and Ras -wild-type lesions

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Isotype-specific functions of Raf kinases

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Abrogation of c-Raf expression induces apoptosis in tumor cells.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Cell cycle targets of Ras/Raf signalling

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Akt is more than just a Bad kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Lipid-Regulated Kinases: Some Common Themes at Last

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PIK3CA as an oncogene in cervical cancer

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

ralGDS family members interact with the effector loop of ras p21.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Ras-dependent activation of the small GTPase Ral.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Stimulation of gene induction and cell growth by the Ras effector Rlf

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The antitumor phospholipid analog, hexadecylphosphocholine, activates cellular phospholipase D

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Hexadecylphosphocholine and 2-modified 1,3-diacylglycerols as effectors of phospholipase D

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The first crystal structure of a phospholipase D

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Choline kinase inhibitors as a novel approach for antiproliferative drug design

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Increased choline kinase activity and elevated phosphocholine levels in human colon cancer

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Choline phosphate and phorbol ester potentiate the mitogenic effect of insulin by competitive mechanisms in NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Phase I clinical/pharmacokinetic and pharmacodynamic trial of the c-raf-1 antisense oligonucleotide ISIS 5132 (CGP 69846A).

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Antisense raf oligodeoxyribonucleotide is a radiosensitizer in vivo

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Synergistic anti-tumoral effect of paclitaxel (Taxol) AS101 in a murine model of B16 melanoma: association with ras-dependent signal-transduction pathways

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Protein prenylation: more than just glue?

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Regulation of endocytic traffic by rho family GTPases.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PRK1 is targeted to endosomes by the small GTPase, RhoB

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Characterization of a novel protein-binding module--the WW domain

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Structure of Cdc42 bound to the GTPase binding domain of PAK

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Structural basis of inhibitor selectivity in MAP kinases

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Novel anti-cancer agents in development: exciting prospects and new challenges

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Discovering novel chemotherapeutic drugs for the third millennium

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Flavonoids and the inhibition of PKC and PI 3-kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1016/S0079-6603(01)67029-6

7 January 2021

10.1016/S0079-6603(01)67029-6

Identifiers

DOI

1 reference

1 August 2017

1 reference