Sleeping giants: emerging roles for the fat cadherins in health and disease (Q34347563)

1 August 2017

title

Sleeping giants: emerging roles for the fat cadherins in health and disease (English)

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1 August 2017

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1 August 2017

Rick F Thorne

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ORCID Public Data File 2021

author name string

Elham Sadeqzadeh

series ordinal

1

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1 August 2017

publication date

29 May 2013

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Medicinal Research Reviews

1 August 2017

published in

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1 August 2017

volume

34

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1 August 2017

issue

1

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1 August 2017

page(s)

190-221

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E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis

1 August 2017

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Connexin-based signaling in acute myelogenous leukemia (AML).

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Tight junction biology and kidney dysfunction

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Functional correlation between cell adhesive properties and some cell surface proteins

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Surface antigen in early differentiation

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Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium.

21 January 2018

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Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members

21 January 2018

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New insights into Fat cadherins

21 January 2018

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Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

21 January 2018

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Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

21 January 2018

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Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster.

21 January 2018

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The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.

21 January 2018

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Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs

21 January 2018

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Cloning and expression of the large zebrafish protocadherin gene, Fat.

21 January 2018

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Cadherins in brain morphogenesis and wiring

21 January 2018

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Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila

21 January 2018

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The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

21 January 2018

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The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity.

21 January 2018

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Upstream regulation of the hippo size control pathway

21 January 2018

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The Hippo Signaling Pathway in Development and Cancer

21 January 2018

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Hippo signaling: growth control and beyond

21 January 2018

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Hippo signaling in Drosophila: recent advances and insights

21 January 2018

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21 January 2018

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Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

21 January 2018

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Delineation of a Fat tumor suppressor pathway

21 January 2018

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

21 January 2018

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

21 January 2018

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Yorkie: the final destination of Hippo signaling.

21 January 2018

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In vivo regulation of Yorkie phosphorylation and localization.

21 January 2018

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Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

21 January 2018

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Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat

21 January 2018

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Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling.

21 January 2018

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Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

21 January 2018

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Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

21 January 2018

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Morphogen control of wing growth through the Fat signaling pathway.

21 January 2018

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Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed

21 January 2018

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Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation

21 January 2018

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Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains

21 January 2018

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Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

21 January 2018

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Drosophila lowfat, a novel modulator of Fat signaling.

21 January 2018

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Processing and phosphorylation of the Fat receptor

21 January 2018

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Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

21 January 2018

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Cell interactions and planar polarity in the abdominal epidermis of Drosophila.

21 January 2018

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Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity

21 January 2018

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Progress and challenges in understanding planar cell polarity signaling.

21 January 2018

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Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila

21 January 2018

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The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.

21 January 2018

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Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat.

21 January 2018

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The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary

21 January 2018

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Modelling planar polarity of epithelia: the role of signal relay in collective cell polarization

21 January 2018

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The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals

21 January 2018

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Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells

21 January 2018

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Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

21 January 2018

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The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins

21 January 2018

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Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

21 January 2018

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Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

21 January 2018

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Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

21 January 2018

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Signal transduction by the Fat cytoplasmic domain.

21 January 2018

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Planar cell polarity signaling in vertebrates

21 January 2018

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Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.

21 January 2018

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In vivo analysis of the Notch receptor S1 cleavage

21 January 2018

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Principles of planar polarity in animal development

21 January 2018

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Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila

21 January 2018

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A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains

21 January 2018

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The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal

21 January 2018

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The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs

21 January 2018

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The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization

21 January 2018

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Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

21 January 2018

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Planar cell polarity: fashioning solutions

21 January 2018

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Fidelity in planar cell polarity signalling.

21 January 2018

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Planar cell polarity: one or two pathways?

21 January 2018

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The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila

21 January 2018

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Drosophila egg chamber elongation: insights into how tissues and organs are shaped

21 January 2018

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Expression profile of the cadherin family in the developing Drosophila brain

21 January 2018

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Expression patterns of cadherin genes in Drosophila oogenesis

21 January 2018

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A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation.

21 January 2018

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Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.

21 January 2018

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Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule

21 January 2018

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Cloning and expression throughout mouse development of mfat1, a homologue of the Drosophila tumour suppressor gene fat.

21 January 2018

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Expression of the rat homologue of the Drosophila fat tumour suppressor gene

21 January 2018

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MEGF1/fat2 proteins containing extraordinarily large extracellular domains are localized to thin parallel fibers of cerebellar granule cells

21 January 2018

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Temporal and spatial expression profiles of the Fat3 protein, a giant cadherin molecule, during mouse development

21 January 2018

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Identification of new human cadherin genes using a combination of protein motif search and gene finding methods

21 January 2018

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Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney

21 January 2018

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Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

21 January 2018

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C-cadherin ectodomain structure and implications for cell adhesion mechanisms

21 January 2018

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Mechanism and dynamics of cadherin adhesion

21 January 2018

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Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics

21 January 2018

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Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus

21 January 2018

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Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

21 January 2018

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Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility

21 January 2018

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A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

21 January 2018

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Effects of Vesl/Homer proteins on intracellular signaling

21 January 2018

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NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

21 January 2018

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Molecular morphogens for dendritic spines

21 January 2018

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Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele.

21 January 2018

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Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21.

21 January 2018

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Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells

21 January 2018

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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype

21 January 2018

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EMT as the ultimate survival mechanism of cancer cells

21 January 2018

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Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

21 January 2018

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

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The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway

21 January 2018

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The Hippo pathway regulates Wnt/beta-catenin signaling

21 January 2018

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Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening

21 January 2018

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Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes

21 January 2018

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FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools

21 January 2018

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Distinct haematological disorder with deletion of long arm of no. 5 chromosome

21 January 2018

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A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

21 January 2018

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Control of neuronal morphology by the atypical cadherin Fat3

21 January 2018

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Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse

21 January 2018

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The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

21 January 2018

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An evolutionary shift in the regulation of the Hippo pathway between mice and flies

21 January 2018

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Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

21 January 2018

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The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

21 January 2018

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A large deletion of the long arm of chromosome No. 4 in a child with limb abnormalities

21 January 2018

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A t(4;9)(q34;p22) translocation associated with partial epilepsy, mental retardation, and dysmorphism

21 January 2018

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Interstitial deletion 4q32-34 with ulnar deficiency: 4q33 may be the critical region in 4q terminal deletion syndrome

21 January 2018

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Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder.

21 January 2018

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No influence of FAT polymorphisms in response to aripiprazole

21 January 2018

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Chromosome 4 deletions are frequent in invasive cervical cancer and differ between histologic variants.

21 January 2018

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A region on human chromosome 4 (q35.1-->qter) induces senescence in cell hybrids and is involved in cervical carcinogenesis.

21 January 2018

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Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma

21 January 2018

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FAT, E-cadherin, beta catenin, HER 2/neu, Ki67 immuno-expression, and histological grade in intrahepatic cholangiocarcinoma

21 January 2018

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Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array

21 January 2018

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Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

21 January 2018

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Immunohistological localisation of human FAT1 (hFAT) protein in 326 breast cancers. Does this adhesion molecule have a role in pathogenesis?

21 January 2018

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Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products

21 January 2018

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

21 January 2018

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

21 January 2018

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Identification of Fat4 as a candidate tumor suppressor gene in breast cancers

21 January 2018

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Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer

21 January 2018

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The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia

21 January 2018

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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

21 January 2018

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Exome sequencing identifies GRIN2A as frequently mutated in melanoma

21 January 2018

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

21 January 2018

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

21 January 2018

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Zyxin Links Fat Signaling to the Hippo Pathway

21 January 2018

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Gene-expression profiling and array-based CGH classify CD4 CD56 hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.21286

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1 August 2017

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